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Extractive of compound rice fermented with red yeast and preparation of hepatic protectant and application

A technology of extracts and medicines, applied in the field of compound pharmaceutical compositions

Inactive Publication Date: 2005-08-31
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no other class of drugs that can replace this class of drugs in terms of lowering low-density lipoprotein, treating coronary heart disease, and preventing cardiovascular events.

Method used

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  • Extractive of compound rice fermented with red yeast and preparation of hepatic protectant and application
  • Extractive of compound rice fermented with red yeast and preparation of hepatic protectant and application
  • Extractive of compound rice fermented with red yeast and preparation of hepatic protectant and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1: Preparation of Red Yeast Extract + Bifendate Ordinary Tablets.

[0044] Prescription: 1000 tablets

[0045] Red Yeast Extract 250g

[0046] Bifendate 25g

[0047] Microcrystalline Cellulose 100g

[0048] Sodium carboxymethyl starch 14g

[0049] Polyvinylpyrrolidone 5g

[0050] Micronized silica gel 4g

[0051] Magnesium Stearate 2g

[0052] Preparation method: pass the medicine and auxiliary materials through 80-mesh sieve respectively, weigh the prescription amount of red yeast rice extract, bifendate, microcrystalline cellulose, sodium carboxymethyl starch (2 / 3), and use 5% polyvinylpyrrolidone 75% solution is made of soft material, passed through a 16-mesh sieve, dried, granulated, added with the remaining sodium carboxymethyl starch, magnesium stearate, and micro-powdered silica gel, and directly compressed into tablets to obtain the product.

Embodiment 2

[0053] Example 2: Preparation of red yeast extract + bifendate sustained-release capsules.

[0054] prescription:

[0055] Sustained release part:

[0056] Dosage per capsule

[0057] Bifendate (80 mesh fine powder) 20mg

[0058] Red Yeast Extract (80 mesh fine powder) 150mg

[0059] Hypromellose 105mg

[0060] 5% povidone 95% ethanol solution 3mg

[0061] Quick release part:

[0062] Dosage per capsule

[0063] Bifendate (80 mesh fine powder) 5mg

[0064] Red Yeast Extract (80 mesh fine powder) 50mg

[0065] Starch 25mg

[0066] 10% starch slurry appropriate amount

[0067] Talc 4mg

[0068] Preparation:

[0069] 1) Immediate release part: take bifendate, red yeast rice extract, and starch, mix well, add appropriate amount of starch slurry to make soft material, pass through 18-mesh nylon sieve, make wet granules, dry at 60-70°C, and sieve for granulation.

[0070] 2) Sustained-release part: take bifendate, r...

Embodiment 3

[0072] Example 3: Preparation of Red Yeast Extract+Malotilate Film-Coated Tablets.

[0073] Prescription: 1000 tablets

[0074] Red Yeast Extract 200g

[0075] Malotilate 100g

[0076] Microcrystalline Cellulose 115g

[0077] Croscarmellose Sodium 13g

[0078] Sodium carboxymethyl starch 9g

[0079] Polyvinylpyrrolidone 6g

[0080] Micronized silica gel 4.5g

[0081] Magnesium Stearate 2.5g

[0082] Preparation method: Pass the medicine and auxiliary materials through an 80-mesh sieve, weigh the red yeast rice extract, malotilate, microcrystalline cellulose, cross-linked sodium carboxymethyl cellulose, sodium carboxymethyl starch (add 2 / 3 ), mix evenly, make a soft material with 5% polyvinylpyrrolidone and 75% ethanol solution, sieve, dry, granulate, add the remaining disintegrant, micropowder silica gel, magnesium stearate, and directly compress the powder into tablets. The prepared tablets are film-coated.

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Abstract

A medicine contains red koji extract, liver-protecting medicine, skeleton material and medicinal additive. A packing box is also disclosed, which includes 60 tablets of red koji extract and 60 tablets of liver-protecting medicine.

Description

Technical field: [0001] The invention relates to a compound pharmaceutical composition composed of two kinds of medicines. The composition contains red yeast rice extract and liver-protecting medicine, especially relates to containing 10-500 mg of red yeast rice extract, 5-500 mg of liver-protecting medicine, appropriate amount of skeleton material and appropriate amount of Pharmaceutical preparations with pharmaceutically acceptable excipients. [0002] The invention also relates to a packaging box, which contains 60 tablets of red yeast rice extract of 10-500 mg and 60 tablets of liver-protecting medicine of 5-500 mg. Background technique: [0003] As a traditional Chinese medicine, red yeast rice is recorded in "Pharmacopoeia of the People's Republic of China" and "Dictionary of Chinese Medicine". Description Red koji, also known as red koji, is prepared by inoculating Monascus on rice and fermenting it. In recent years, relevant scholars at home and abroad have continu...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61P1/16
Inventor 鄂滟蔡金巧
Owner FUKANGREN BIO PHARMA
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