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Paeonal injection emulsion for anti-tumor and its preparing method

A technology for paeonol and anti-tumor, applied in the field of paeonol injection emulsion and preparation thereof, can solve the problems of slow dissolution rate of oral tablets, inability to combine paeonol, poor stability of injection, etc., and achieves easy expansion of production and production. Simple conditions and equipment, and the effect of improving solubility

Inactive Publication Date: 2005-10-19
SHANDONG ACAD OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral tablets have slow dissolution rate and low bioavailability; while injections have poor stability and large doses (about 17mg / Kg), anticancer treatment injections can take dosage forms such as inclusion, solubilization and liposome entrapment. Preparation of dosage forms is complicated and unstable, and the drug content is low, making it difficult to meet the requirements
[0004] Ganoderma lucidum polysaccharide is also used for anti-tumor treatment, but it is a water-soluble drug and cannot be organically combined with paeonol

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Drug 1 Paeonol 70mg;

[0026] Drug 2 Ganoderma lucidum polysaccharide 30mg;

[0027] Water Phase Physiological Saline 5ml

[0028] Oil phase ethyl linoleate 150mg

[0029] Emulsifier 1 polyoxyethylene castor oil appropriate amount

[0030] Emulsifier 2 Poloxmer 188 appropriate amount

[0031] Co-emulsifier 1, 2 Propylene Glycol Appropriate amount.

Embodiment 2

[0033] Drug 1 Paeonol 30mg;

[0034] Drug 2 Ganoderma lucidum polysaccharide 60mg;

[0035] Aqueous phase 5% glucose infusion 3ml

[0036] Oil Phase Refined Vegetable Oil 50mg

[0037] Emulsifier 1 polyoxyethylene castor oil appropriate amount

[0038] Emulsifier 2 Tween 80 appropriate amount

[0039] Co-emulsifier 1, 2 Propylene Glycol Appropriate amount.

Embodiment 3

[0041] Drug 1 Paeonol 10mg;

[0042] Drug 2 Ganoderma lucidum polysaccharide 80mg;

[0043] Aqueous phase pH=7.4 Isotonic phosphate buffer 5ml

[0044] Oil Phase Oil for Injection 100mg

[0045] Emulsifier 1 Lecithin Appropriate amount

[0046] Emulsifier 2 Poloxmer 188 appropriate amount

[0047] Appropriate amount of co-emulsifier PEG400.

[0048] The preparation method of the above drug emulsion is as follows: pulverize paeonol, put it in a suitable container, fully mix and dissolve it with the oil phase to form a transparent solution; dissolve the emulsifier 1, emulsifier 2 and co-emulsifier with an appropriate amount of oil phase and then transfer to the above solution In the process, mix well and evenly to obtain the medicinal oil phase; mix and dissolve the Ganoderma lucidum polysaccharide with the water phase in a suitable container to form the medicinal water phase; slowly add the medicinal water phase to the medicinal oil phase under low-spee...

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PUM

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Abstract

The present invention relates to paeonal injection emulsion for treating tumor and is preparation process. The emulsion consists of liposoluble paeonal and water soluble glossy ganoderma polysaccharide as effective components. The paeonal injection emulsion has high and fast curative effect on tumor, high medicine content, and less toxic side effect.

Description

(1) Technical field [0001] The invention relates to a paeonol injection emulsion for treating tumors and a preparation method thereof. (2) Background technology [0002] Paeonol is one of the main active ingredients of Cortex Moutan, which has a wide range of pharmacological activities, including antipyretic, analgesic, antibacterial and anti-inflammatory, anti-atherosclerosis, inhibition of platelet aggregation, enhancement of cellular immune function and antioxidant effect, etc. In recent years, the anti-tumor effects of paeonol in vivo and in vitro have gradually attracted the attention of people in the industry. [0003] Paeonol is a fat-soluble drug with a peculiar smell and slightly spicy taste. It is soluble in ethanol and methanol, insoluble in cold water, slightly soluble in hot water, and easy to sublimate. It is available in ointment, sugar-coated tablets and other dosage forms. Oral tablets have slow dissolution rate and low bioavailability; while injections hav...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P35/00
Inventor 武继彪张贞丽胡新隋在云侯新朴
Owner SHANDONG ACAD OF CHINESE MEDICINE
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