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Method for preparing active monomer peonol from paniculate swallowwort root

A kind of active monomer, Xu Changqing's technology, applied in ether preparation, ether separation/purification, organic chemistry, etc., can solve the problems of no paeonol patent literature report, cumbersome preparation process, slow extraction speed, etc., and achieve high price , wide application prospects and fast extraction speed

Inactive Publication Date: 2005-10-19
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method has obvious disadvantages: slow extraction speed, high energy consumption, cumbersome preparation process, low yield, and sewage treatment problems due to the use of a large amount of water.
No patent literature report on the preparation of paeonol by ultrasonic extraction has been found through retrieval

Method used

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  • Method for preparing active monomer peonol from paniculate swallowwort root

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Bake 500g of the root of Xu Changqing at 60°C for 4 hours, crush it to 10 meshes, put the medicinal material powder into the reaction vessel of the ultrasonic extraction device, add 8 times the amount of petroleum ether with a boiling range of 30-60°C, and extract it ultrasonically for 2 hours (ultrasonic frequency 5000Hz). The filtered extract was refrigerated at 2°C for 4 hours to obtain pale yellow crystals, which were crude paeonol. Add 2 times the amount of 80% ethanol, control the temperature at 80°C, heat for 10 minutes, filter, and stand for crystallization for 5 hours to obtain nearly colorless crystals. The crystals were vacuum-dried at room temperature for 2 hours to obtain paeonol fine product, and the yield of paeonol was 1.24%.

Embodiment 2

[0019] Dry 500g of the root of Xu Changqing at 50°C for 4 hours, crush it to 30 meshes, put the medicinal material powder into the reaction vessel of the ultrasonic extraction device, add 9 times the amount of petroleum ether with a boiling range of 30-60°C, and extract it ultrasonically for 3 hours (ultrasonic frequency 5000Hz). The filtered extract was refrigerated at 3°C ​​for 6 hours to obtain pale yellow crystals, which were crude paeonol. Add 3 times the amount of 80% ethanol, control the temperature at 80°C, heat for 10 minutes, filter, and stand for crystallization for 4 hours to obtain nearly colorless crystals. The crystals were vacuum-dried at room temperature for 2 hours to obtain paeonol fine product, and the yield of paeonol was 1.31%.

Embodiment 3

[0021] Dry 500g of the root of Xu Changqing at 40°C for 4 hours, crush it to 50 meshes, put the medicinal material powder into the reaction vessel of the ultrasonic extraction device, add 10 times the amount of petroleum ether with a boiling range of 30-60°C, and extract it ultrasonically for 4 hours (ultrasonic frequency 5000Hz). The filtered extract was refrigerated at 2°C for 5 hours to obtain pale yellow crystals, which were crude paeonol. Add 4 times the amount of 80% ethanol, control the temperature at 80°C, heat for 10 minutes, filter, and stand for crystallization for 5 hours to obtain nearly colorless crystals. The crystal was vacuum-dried at room temperature for 2 hours to obtain paeonol fine product, and the yield of paeonol was 1.35%.

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Abstract

The present invention relates to the preparation of peonol, and is especially the method of preparing high-purity active monomer peonol from paniculate swallowwort root. The present invention adopts dry paniculate swallowwort root powder as material and petroleum ether as extracting solvent to obtain coarse peonol, and through ulatrsonic extraction at frequency of 20-60 KHz for 1 hr or more time and cooling crystallization of the extract liquid, and obtains high-purity monomer peonol through further re-crystallization in ethanol and drying. The extract prepared with paniculate swallowwort root has target component content as high as 88.3 %. The present invention has simple preparation process, easy purification, fast extraction speed, high extracting rate and relax requirement on equipment, and is suitable for industrial production.

Description

technical field [0001] The invention relates to the preparation of paeonol, in particular to a method for extracting and preparing high-purity active monomer paeonol from the root of Xu Changqing by ultrasonic technology. Background technique [0002] Paeonol has obvious pharmacological activities such as antibacterial and anti-inflammatory, analgesic and sedative, lowering blood pressure, inhibiting atherosclerosis, promoting platelet aggregation and enhancing immune function. Paeonol-rich paeonol, Xu Changqing (the original plant is Cynanchum paniculatum (Bge.) Kitag.) and other traditional Chinese medicines are widely used clinically to treat thrombocytopenic purpura, bacillary dysentery and headache, etc. disease. [0003] Extraction of paeonol from plants usually adopts steam distillation: usually first use high-temperature steam to bring paeonol to the distillate, then extract paeonol in the distillate with ether, and then dry and distill off the ether, Finally, the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C41/34C07C43/253
Inventor 梁鑫淼张峰徐青肖红斌
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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