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Method for realizing concentration measurement by employing flotation benchmarks

A concentration measurement and benchmarking technology, applied in scattering characteristics measurement, diagnostic recording/measurement, application, etc., can solve problems such as the inability to effectively eliminate the influence of interference signals, limit the detection accuracy of trace components, etc., to improve the accuracy and measurement accuracy. , the effect of eliminating noise

Active Publication Date: 2012-05-09
TIANJIN SUNRISE TECH DEV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these three methods have their own different defects: a. Transmission method: Since the light source and detector are respectively arranged on both sides of the inspected part to receive the light passing through the human tissue, what it receives is the light path Through all the information on the path, however, due to the great differences in the measured individuals themselves, even compared to the same individual, the tissue differences at different times are also very serious, thus limiting the detection accuracy of transmission for trace components in the human body; b, Attenuated total reflection (ATR) method: The principle of total reflection is used to make the sample and the beam interact multiple times to improve the sensitivity of the output signal to the active components. However, the ATR method only measures the information on the surface of the medium, and in actual measurement, the surface layer There is a big difference between the blood glucose concentration and the actual blood glucose concentration; c. Diffuse reflection method: the light source and the detector are located on the same side of the tested part, and the signal of the received light comes from the backscattered light component of the tissue. The advantage is that the emission and reception All are on the same side of the measured medium, reducing the influence of individual differences and site differences
[0005] In summary, the prior art cannot effectively eliminate the influence of interference signals in the diffuse reflectance spectroscopy measurement, which is exactly the problem to be solved by the present invention

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  • Method for realizing concentration measurement by employing flotation benchmarks
  • Method for realizing concentration measurement by employing flotation benchmarks
  • Method for realizing concentration measurement by employing flotation benchmarks

Examples

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example 1

[0087] Example 1: Optical path selection method for measuring lactose content in milk

[0088] The main content of this program is to study the relationship between the absorption coefficient and scattering coefficient of milk with lactose concentration through experiments; then apply formula (5) to find the position of maximum sensitivity and minimum sensitivity Location.

[0089] The experimental device adopts a double integrating sphere system, and the light source is the FTIR spectrometer of PE Company, such as Figure 5 shown. Weigh 500, 1000, 1500, 2000, 2500, 3000, 3500, 4000, 4500, 5000 mg of lactose respectively, put them in a 50ml volumetric flask, and then add pure milk to the mark respectively. The diffuse reflectance Rd, diffuse transmittance Tt, and collimated transmittance Tc of each sample were measured in turn, and then Rd, Tt, and Tc were substituted into the inverse multiplication program to calculate the rate of change of the absorption coefficient and re...

example 2

[0094] Example 2: Optical path selection scheme for measuring glucose content in human skin

[0095] In this embodiment, the net analytical signal of glucose refers to the only useful signal in the measured human blood medium corresponding to the change of blood glucose, which is orthogonal to the space formed by all interference signals, and is the subtraction The pure analytical signal of the measured analyte after the interference vector. For non-invasive blood glucose measurement and detection, its data preprocessing needs to use net signal analysis and processing. The spectral signal is the result of the joint influence of various components in the blood and the physiological state of the skin surface. The noise space I in the net signal calculation is constructed by using the spectrum of the signal constant point C I C + , where I C is the spectral matrix measured at point C, I C + for the matrix I C pseudo-inverse of . This noise space has the same noise signal ...

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Abstract

The invention relates to a method for measuring concentration by using floating reference, which comprises the following steps: according to a rate of change of light intensity with the concentration of an object to be measured at different positions away from a light source (or different measuring times at the same position), obtaining measuring points and reference points required by the measurement, and using the light intensity measuring value at the reference points and the measuring points to realize the measurement of component concentration in the object to be measured. The invention is characterized in that the method includes the following steps: measuring the light intensity parameters at the reference points; measuring light intensity parameters at the measuring points; performing data pretreatment to the measuring results, performing difference treatment to signals at the measuring points based on the light intensity at the reference points, establishing a correction model between the concentration and the light intensity difference signal; and realizing the measurement of the concentration of the object to me measured. Compared with the prior art, the invention not only eliminates the noise effectively and in the maximal degree through the pretreatment to the signals, but also allows the weak signals to be displayed maximally, improves the measurement precision, especially improves the precision of the human blood sugar concentration measurement without wound.

Description

technical field [0001] The invention relates to a method for measuring substance concentration by near-infrared spectroscopy, in particular to a method for realizing substance concentration measurement by using a floating reference method. Background technique [0002] Currently, near-infrared spectroscopy is widely used to measure the concentration of substances. Among them, the non-invasive measurement of human blood glucose concentration by near-infrared spectroscopy is one of the frontier topics attracting worldwide attention. It can not only realize timely, safe and painless self-monitoring of blood glucose concentration, but also does not require consumables, which can greatly reduce the cost of testing. At the same time, the establishment of this theoretical method is not only applicable to blood glucose measurement, but also can be extended to other components in body fluids The non-invasive detection is of great significance to the development of medical detection ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/47G06F19/00A61B5/1455
Inventor 徐可欣罗云瀚刘蓉陈文亮
Owner TIANJIN SUNRISE TECH DEV