Soft capsule contg. clinopodium polycephalum and preparing method thereof

A technology for breaking blood flow and soft capsules, applied in the directions of capsule delivery, blood diseases, pharmaceutical formulations, etc., can solve the problems of shortening clotting time, nausea reaction, etc., and achieve the effect of eliminating absorption, convenient storage, and no harmful residues.

Inactive Publication Date: 2006-03-29
浙江天一堂集团限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The long-term poisoning test in dogs shows that the total glucosides of 30 and 120mg / kg doses of blood flow can be continuously administered to dogs for 4 weeks, and the blood coagulation time can also be shortened (consistent with the drug effect), and the hematological indicators, blood biochemical indicators, and visceral indicators can also be shortened. The coefficient, general condition, autopsy and pathological examination showed no obvious abnormalities, but the high-dose dogs had nausea, which may be caused by saponin stimulation of the gastric mucosa, and the low-dose did not have any abnormal reactions, and the nausea in the high-dose group disappeared after stopping the drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take 5Kg off blood stream and add water to decoct twice, each time for 1.5 hours, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.15 (80°C), add 1.7 times the amount of ethanol, stir well, let stand for 24 hours, take the The clear liquid was recovered from ethanol and concentrated into a thick paste, dried under reduced pressure and crushed into fine powder.

[0032] Weigh 2000g of Duanxueliu ointment powder, 2500g of gelatin, 875g of glycerin, 10g of antioxidant, 0.7g of preservative, 2000g of vegetable oil, 50g of beeswax, and put gelatin, glycerin and water in the plastic bucket according to the ratio of 1:0.35:1 , heated at 90°C to dissolve, added preservatives, stirred for 2 hours at the same time, vacuumed and degassed, and kept at 70°C for later use.

[0033] Add beeswax to vegetable oil to dissolve, add Duanxueliu ointment powder, stir evenly, add antioxidant, pass colloid mill for later use. Adjust the temperature of the...

Embodiment 2

[0035] Weigh Duanxueliu ointment powder 1000g, gelatin 400g, glycerin 140g, antioxidant 5g, preservative 0.4g, PEG 400 2000g, 50g of beeswax, put gelatin, glycerin, and water in a plastic bucket at a ratio of 1:0.35:1, heat and dissolve in a water bath at 95°C, add preservatives, stir for 2 hours at the same time, vacuumize and degas, and keep warm at 80°C for later use.

[0036] Add beeswax to vegetable oil to dissolve, add Duanxueliu ointment powder, stir evenly, add antioxidant, pass colloid mill for later use. Adjust the temperature of the plastic box of the SCM-100 soft capsule machine to 50°C, the temperature of the spray body to 41-43°C, and the thickness of the rubber to 0.7-0.8mm. Pour the medicinal liquid into the medicinal liquid hopper, and press the soft capsule with a mold.

Embodiment 3

[0038] Weigh 1500g of Duanxueliu ointment powder, 1500g of gelatin, 525g of glycerin, 8g of antioxidant, 0.5g of preservative, 1500g of vegetable oil, and 40g of beeswax. Heat and dissolve in a water bath at 80°C, add preservatives, and stir for 2 hours at the same time, after vacuuming and degassing, keep warm at 55°C for later use.

[0039] Add beeswax to vegetable oil to dissolve, add Duanxueliu ointment powder, stir evenly, add antioxidant, pass colloid mill for later use. Adjust the temperature of the plastic box of the SCM-100 soft capsule machine to 50°C, the temperature of the spray body to 41-43°C, and the thickness of the rubber to 0.7-0.8mm. Pour the medicinal liquid into the medicinal liquid hopper, and press the soft capsule with a mold.

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PUM

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Abstract

A softgel of Duanxueliu is composed of a core prepared from the powdered extract of Duanxueliu and auxiliary including antioxidizing agent and a shell prepared from gelatin, glycerin, water and antiseptic agent. Its preparing process includes such steps as mixing glycerin with water, adding gelatin and antiseptic agent, heating while stirring, vacuumizing for defoaming, filter, holding its temp, dissolving beeswax in liquid matrix, adding powdered extract of Duanxueliu, stirring, adding antioxidizing agent, colloid grinding, loading them in softgel forming machine and shaping.

Description

technical field [0001] The invention relates to a traditional Chinese medicine soft capsule and a preparation method thereof, in particular to a traditional Chinese medicine Duanxueliu soft capsule made from a single herb Duanxueliu as a raw material and a preparation method thereof. Background technique [0002] Duanxueliu is the dry above-ground part of Ladiatas genus Ladiatas, which has the effects of clearing away heat and detoxifying, hemostasis and promoting blood circulation. Bleeding, traumatic bleeding, etc. There are 11 species of Ladiatas ClinopodiumLinn in the Labiatae family [1], of which 5 are commonly used as medicinal materials and are mainly distributed in the vast areas of my country except the Northeast. (1) Clinopodium chinense (Benth.) Kuntze is distributed in Zhejiang, Jiangxi, Fujian, Guangdong, Guangxi, Guizhou and other places. (2) Clinopodium poiyyephalum (Vaniot) C.Y.Wu et Hsuan is mainly distributed in Jiangsu, Anhui, Gu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61K9/48A61P7/04
Inventor 王天亮樊雪君王永华
Owner 浙江天一堂集团限公司
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