Nano carbon tube infusion agent, its prepn. method and application in treating cancer, cardiovascular disease and infectious disease

A technology of carbon nanotubes and infusion agents, which can be used in the treatment of cancer, cardiovascular and cerebrovascular diseases, applications in diseases, applications in infectious diseases, and the field of carbon nanotube infusion solutions, which can solve the problems of insufficient research and application of carbon nanotubes. , to achieve no immunogenicity, no toxic side effects, good compatibility

Inactive Publication Date: 2006-03-29
陈小川
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Carbon nanotubes have been widely used in the fields of heat, electricity, optics, chemistry, etc., but in the field of pharmaceuticals, there are still very few studies and applications of carbon nanotubes, especially in infusion solutions. So far, there has been no use of carbon nanotubes. The precedent of using carbon nanotubes as infusion solution and carrier

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Preparation of pure carbon nanotube microparticle injection:

[0067]Take 0.5 kg of carbon nanotubes, the diameter of which is 2 nm, the length of the carbon nanotubes is 100 μm, and the pore diameter is 1 nm. Then it is input into an air cutter for cutting, and the main particle size distribution range is controlled to be 2nm in diameter, 3μm-1nm in tube length, and 99% of the pore size is 1nm. Use carbon nanotube micropowder as solute and dimethyl sulfoxide (DMSO) as suspending solvent to prepare 5000ml of 1% carbon nanotubes, and pack into 1ml or 2ml infusion solutions per bottle under strong magnetic stirring.

Embodiment 2

[0069] Preparation of activated carbon nanotube particle injection:

[0070] 100g of carbon nanotubes, add 300ml of 1% thionyl chloride / chloroform solution at -10°C, stir for 2 hours, centrifuge at 20,000 rpm to collect the precipitate; then put the sediment container into a pressure vessel and heat to 80°C , 5 minutes later degassing and depressurization to generate oxidized carbon nanotubes; then respectively pass activators into the pressure vessel to generate several activated carbon nanotubes with different active groups:

[0071] If preparing hydroxylated carbon nanotubes, pass through 90°C water vapor for 2 hours, then depressurize and exhaust to generate hydroxylated carbon nanotubes;

[0072] If the imidized carbon nanotubes are prepared, then pass through pure ammonia vapor at 90°C for 2 hours to generate imidized carbon nanotubes;

[0073] If preparing hydroxyl and amino carbon nanotubes, pass through 10-40% ammonia-water vapor at 90°C to generate carbon nanotubes ...

Embodiment 3

[0078] Preparation of drug-loaded carbon nanotube injections:

[0079] ① Adsorption anticancer drug infusion: in the absence of drug antagonism, you can choose any drug for adsorption, for example, cisplatin 6g, 5-FU 0.4g, or cisplatin 6g, 6-MP 0.8g dissolved in 100ml water, add 10g of 120-mesh carbon nanotubes or activated hydroxyl-amino carbon nanotubes are fully adsorbed under stirring; the precipitate is taken by high-speed centrifugation, dehydrated with acetone, centrifuged to take the precipitate, and dried; then the precipitate is impregnated with 0.1% chitosan aqueous solution for 5 minutes. Dehydrated with acetone and dried; pulverized with an air pulverizer, the particle size is controlled to be 35μm-2nm, the main particle size distribution range is 6μm-2nm, of which 3μm-2nm accounts for 99%, and the 6μm-3μm particles do not exceed 1%,; will be exposed after pulverization The drug-loaded carbon nanotube particles with new cross-sections are immersed in 20% porphyrin...

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PUM

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Abstract

A carbon nanotube type perfusion for treating cancer, atherosclerosis, coronary heart disease, cerebral thrombosis, infections disease, poisoning, etc contains heavy metal (less than 0.1-10 ppm), soluble metal ions (less than 0.1-10 ppm) and ash (0-2%). It may be the granular carbon nanotube injection, activated granular carbon nanotube injection, carbon nanotube injection containing catalyst, and medicine carried carbon nanotube injection. Its advantages are high compatibility to tissue, unique curative effect and no toxic by-effect.

Description

technical field [0001] The invention relates to a nano-carbon tube infusion solution, a preparation method thereof and its application in preparation and treatment of diseases such as cancer. More specifically, the present invention relates to the carbon nanotube infusion solution for intravenous infusion, its preparation method and its application in the treatment of cancer, cardiovascular and cerebrovascular diseases, and infectious diseases. Background technique [0002] Since the discovery of carbon nanotubes in 1991, carbon nanotubes have attracted people's attention because of their unique structure, peculiar physical and chemical properties, and their potential application prospects. Carbon nanotubes are tubular materials formed by curling carbon atoms in graphite. The diameter of the tube is generally several nanometers (the minimum is about 1 nanometer) to tens of nanometers, and the thickness of the tube is only a few nanometers. In fact, carbon nanotubes can be v...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/04A61K45/00A61K9/14A61P35/00A61P9/00A61P31/00
Inventor 陈小川
Owner 陈小川
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