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Hydroxy apatite Ni3Al Composite material and its preparing method

A technology of hydroxyapatite and composite materials, which is applied in the field of medical materials, can solve the problems of decreased biocompatibility, accelerated decomposition of hydroxyapatite, and low biological activity, and achieves improved comprehensive performance, high flexural strength and Effects of fracture toughness, good biocompatibility

Inactive Publication Date: 2006-05-24
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the introduction of the second term often leads to a decrease in biocompatibility and may accelerate the decomposition of hydroxyapatite, generally speaking, the biological activity of hydroxyapatite materials enhanced by biologically inert materials will be lower than that of pure hydroxyapatite
Whisker-reinforced hydroxyapatite composites have a good toughening effect, but the whiskers can enter the human body from the hydroxyapatite matrix, which is likely to cause serious health problems and has potential carcinogenicity.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Prepare Ca(NO 3 ) 2 solution and (NH 4 ) 2 HPO 4 solution; Ca(NO 3 ) 2 The solution was added into a three-necked flask, and its pH value was adjusted to 10 with aqueous ammonia, and then (NH 4 ) 2 HPO 4 Add the solution to the separatory funnel;

[0025] (2) The molar ratio of calcium and phosphorus elements is 1.67 (NH 4 ) 2 HPO 4 The solution was added dropwise to the above Ca(NO 3 ) 2 The reaction is carried out in the solution, the titration time is controlled within 1 hour and the stirring state is kept; after the reaction is completed, the product is heated to 90°C in a water bath and kept for 3 hours;

[0026] (3) Naturally cool to room temperature, suction filter the precipitate produced by the reaction, wash it with distilled water to neutrality, and then wash it 3 times with absolute ethanol; then send the precipitate into an electric blower box, and dry it at 120°C for 30 hours. Then calcined at 900°C for 0.6 hours, then cooled, ground and ...

Embodiment 2

[0033] (1) Prepare Ca(NO 3 ) 2 solution and (NH 4 ) 2 HPO 4 solution; Ca(NO 3 ) 2 The solution was added into a three-necked flask, and its pH value was adjusted to 11 with aqueous ammonia, and then (NH 4 ) 2 HPO 4 Add the solution to the separatory funnel;

[0034](2) The molar ratio of calcium and phosphorus elements is 1.67 (NH 4 ) 2 HPO 4 The solution was added dropwise to the above Ca(NO 3 ) 2 The reaction is carried out in the solution, the titration time is controlled within 1 hour and the stirring state is kept; after the reaction is completed, the product is heated to 90°C in a water bath and kept for 3 hours;

[0035] (3) Naturally cool to room temperature, suction filter the precipitate produced by the reaction, wash it with distilled water to neutrality, and then wash it 3 times with absolute ethanol; then send the precipitate into an electric blower box, and dry it at 130°C for 25 hours. Then calcined at 900°C for 1 hour, then cooled, ground and siev...

Embodiment 3

[0042] (1) Prepare Ca(NO 3 ) 2 solution and (NH 4 ) 2 HPO 4 solution; Ca(NO 3 ) 2 The solution was added into a three-necked flask, and its pH value was adjusted to 12 with aqueous ammonia, and then (NH 4 ) 2 HPO 4 Add the solution to the separatory funnel;

[0043] (2) The molar ratio of calcium and phosphorus elements is 1.67 (NH 4 ) 2 HPO 4 The solution was added dropwise to the above Ca(NO 3 ) 2 The reaction is carried out in the solution, the titration time is controlled within 1 hour and the stirring state is kept; after the reaction is completed, the product is heated to 90°C in a water bath and kept for 3 hours;

[0044] (3) Naturally cool to room temperature, suction filter the precipitate produced by the reaction, wash it with distilled water until it is neutral, and then wash it 3 times with absolute ethanol; then send the precipitate into an electric blower box, and dry it at 140°C for 20 hours. Then calcined at 900°C for 2 hours, then cooled, ground ...

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Abstract

The present invention discloses a hydroxyapatite-Ni3Al composite material. Its composition includes (by wt%) 92%-98% of hydroxyapatite and 2%-8% of Ni3Al. Said invention also discloses its preparation method. Firstly, it adopts chemical precipitation method to synthesize hydroxyapatite, and adopts mechanical alloying process and combines it with heat treatment process to prepare Ni3Al intermetallic compound, then uniformly mixes hydroxyapatite and Ni3Al intemetallic compound powder body so as to obtain the invented composite material with good mechanical property and biological compatibility.

Description

technical field [0001] The invention relates to a composite material of an intermetallic compound and a preparation method thereof, in particular to a hydroxyapatite-Ni 3 The invention relates to an Al composite material and a preparation method thereof, which belong to the technical field of medical materials science. Background technique [0002] In the mid-1930s, Nims, Korber and Tromel first synthesized hydroxyapatite, which started a new era of hydroxyapatite application. Through clinical application, it is found that the material has excellent biological activity, has good biocompatibility with animal tissues, has no toxic side effects, has osteoconductivity, can provide a physiological scaffold for the precipitation of new bone, and can form direct contact with bone tissue. Osseointegration is an artificial bone material with excellent biological properties, so it is widely used in clinical non-load-bearing bone and filling, while in the application of large-scale bo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40
Inventor 孙康宁孙昌
Owner SHANDONG UNIV
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