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Chinese medicinal composition for treating chronic bronchitis and its preparation method

A technology of chronic bronchitis and composition, which is applied in the direction of drug combination, medical formula, medical preparations containing active ingredients, etc., can solve the problems of slow effect, large dose, long course of treatment, etc., and achieve complete extraction, small dose, and full effect

Inactive Publication Date: 2006-06-14
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the traditional Chinese medicines currently used for the treatment of chronic bronchitis take large doses, take effect slowly, have a long course of treatment, and are prone to relapse

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The acquisition of embodiment 1 pepper fat oil and volatile components

[0025] Take 6000g of the medicinal material of pepper, grind it into 40-mesh powder as the pressing material, and press it with a hydraulic oil press at a temperature of 80°C and a pressure of 50Mpa. The results are shown in Table 1 below.

[0026] experiment

Embodiment 2

[0027] The preparation of embodiment 2 pharmaceutical capsule preparations of the present invention

[0028] Take 500g of pepper, grind it into 20-50 mesh powder, squeeze it with a hydraulic oil press at a temperature of 60-90°C and a pressure of 40-70Mpa, collect fat oil and volatile components, that is, 92g of the pepper oil component. Save the dregs. Take 333g of epimedium, 333g of silkworm, 500g of radish seed, mix them with the medicinal residue of pepper, and extract twice with 55-65% ethanol under reflux, the first time is 7 times the amount, reflux extraction for 1 hour, and the second time 5 times the amount , reflux extraction for 1 hour, combined two alcoholic extracts, recovered ethanol, and obtained alcoholic extract; added water to extract twice, the first time added 10 times the amount of water, extracted for 1 hour, and added 8 times the amount of water for the second time to extract After 1 hour, the two water extracts were combined and concentrated to obtain...

Embodiment 3

[0029] The efficacy test of embodiment 3 medicine of the present invention

[0030](1) Effects on the pulmonary lesions of Sendai virus-infected mice

[0031] The mice were randomly divided into 6 groups, normal control group, virus model group, ribavirin group, cough and asthma soft high, medium and low dose groups, 12 in each group, half male and half male. The high, medium and low dosage groups of the pharmaceutical soft capsule preparation of the present invention were administered with different concentrations of drugs by gavage respectively, and the virus model group and the normal control group were gavaged with equal volume water twice a day. The mice in the ribavirin group were intraperitoneally injected with ribavirin 0.13 g / kg, twice a day, for 6 consecutive days. After the first administration, the mice were lightly anesthetized with ether, and 50ul / mouse of Sendai virus stock solution was dripped into the nasal cavity. The normal control group was dripped with s...

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Abstract

A Chinese medicine in the form of softgel for treating chronic bronchitis is prepared from 4 Chinese-medicinal materials including batryticated silkworm, radish seed, epimedium, etc. Its preparing process is also disclosed.

Description

[0001] The invention relates to a traditional Chinese medicine composition for eliminating phlegm, relieving cough, invigorating kidney and relieving asthma and a preparation method thereof, which belongs to the field of traditional Chinese medicine pharmacy. Background technique [0002] According to the national census of 60 million people in my country in recent years, the prevalence rate of chronic bronchitis is 3.82%. The prevalence increases with age, reaching 15% or more in those over 50 years of age. If it cannot be controlled in time, it will be delayed repeatedly, and it will develop into chronic obstructive emphysema, cor pulmonale, etc., which will seriously endanger human health. At present, antitussives containing antihistamines and expectorants are mostly used to treat cough and asthma clinically. These drugs can temporarily relieve symptoms in some cases, but in most cases, the long-term effect is not good, and some may even prolong symptoms duration. Althoug...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/67A61K9/14A61K9/20A61K9/48A61K35/64A61P11/00
Inventor 郭立玮张龙卞慧敏文红梅潘林梅陈峰袁铸人沈强
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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