Chuanxiong lactone kind component soft capsule for treating cardiovascular and cerebrovascular diseases
A kind of cardiovascular and cerebrovascular disease and soft capsule technology, which is applied in the field of soft capsules for the treatment of cardiovascular and cerebrovascular diseases with chuanxiong lactones
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Embodiment 1
[0082] Embodiment 1: Chuanxiong lactone component soft capsule
[0083] The following examples illustrate specific embodiments of the present invention, each component of soft capsule preparation is mixed, glue, batching→soft capsule pill press→fluidized bed soft capsule pre-drying machine→ultrasonic soft capsule cleaning machine
[0084] contents
Embodiment 2
[0085] Embodiment 2: Chuanxiong lactone component soft capsule
[0086] The components of soft capsule preparation are mixed, gelatinized and ingredients→soft capsule pellet machine→fluidized bed soft capsule predrying machine→ultrasonic soft capsule cleaning machine
[0087] Ground feeder→track-type automatic dryer→semi-automatic capsule tablet inspection machine→aluminum-plastic inner and outer packaging
[0088] content
Embodiment 3
[0089] Embodiment 3: biological screening method to study the chuanxiong lactone components through the blood-brain barrier, to achieve the time working curve of the therapeutic effect
[0090] 1. Selection of chromatographic conditions
[0091] HPLC: Column Nova-Pak C18 (3.9×150mm); mobile phase: methanol-water-acetic acid (35:65:0.5, V / V / V); flow rate 0.8mL / min; UV detection wavelength: 270nm, 320nm; injection volume: 20μL.
[0092] MS: atmospheric pressure chemical ionization (APCI); scan interval: 1.00s; mass range: m / z 100-300; AP+ detection.
[0093] 2. Experimental results
[0094] The HPLC chromatograms of serum, brain homogenate, blank serum, and blank brain plasma were detected at 270nm after gavage of rats for 2 hr. Figure 4 and Figure 5 shown. In serum and brain homogenate, the retention time of the chuanxiong lactone component chromatographic peak corresponds to the retention time of the Chuanxiong standard fingerprint chromatogram component (see appendix...
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