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Anhydrous topical formulation for polyphenols
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A topical preparation technology, applied in the field of anhydrous topical preparations of polyphenols, which can solve the problems of poor solubility of polyphenols
Inactive Publication Date: 2006-11-01
ORIGIN BIOMEDICINALS
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Abstract
Description
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Problems solved by technology
Saturated or unsaturated vegetable oils are commonly used as bases in a number of commercially available topical mixtures, but polyphenols are poorly soluble in these oils
Method used
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Examples
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Embodiment 1
[0015] Example 1: Acne cream (using salicylic acid)
[0016] An anhydrous formulation for the treatment of acne comprising 3% w / w purified green tea extract (containing at least 70% polyphenols) utilizing 0.5% w / w salicylic acid as an appropriate binding carrier was designed as follows:
[0017] 77.1% jojoba oil
[0018] 15.0% beeswax
[0019] 2.0% Lecithin
[0020] 2.0% Ascorbyl Palmitate (Vitamin C)
[0021] 0.2% sorbic acid
[0022] 3.0% Green Tea Polyphenol Extract (70% Polyphenols)
[0023] 0.5% salicylic acid
[0024] 0.2% tea tree oil
[0025] During formulation it is necessary to first pulverize the polyphenols and bound carrier until homogeneous using mild heat and milling. The polyphenol / carrier is then added to the remainder of the dry mixture upon further mixing and / or milling to obtain a uniformly distributed topical mixture.
Embodiment 2
[0026] Example 2: Skin Cream (Using Silicone)
[0027] A formulation for the treatment of damaged skin comprising 5% w / w purified green tea extract (containing at least 70% polyphenols) utilizing 6% w / w micronized silica gel as an appropriate binding carrier was designed as follows:
[0028] 67.5% jojoba oil
[0029] 5.0% dimethyl sulfone
[0030] 12.0% beeswax
[0031] 2.0% Lecithin
[0032] 6.0% silica gel (micronized)
[0033] 5.0% Green Tea Polyphenol Extract (70% Polyphenols)
[0034] 0.2% sorbic acid
[0035] 2.0% Ascorbyl Palmitate (Vitamin C)
[0036] 0.2% lavender oil
[0037] 0.1% tea tree oil
[0038] It is necessary to pulverize the polyphenols and the combined carrier until uniform in the preparation process. The polyphenol / carrier is then added to the remainder of the dry mixture upon further mixing and / or milling to obtain a uniformly distributed topical mixture.
Embodiment 3
[0039] Example 3: Skin Cream (Using Talc)
[0040] A formulation for the treatment of damaged skin comprising 5% w / w purified green tea extract (containing at least 70% polyphenols) utilizing 20% w / w talc as an appropriate binding carrier was designed as follows:
[0041] 58.5% jojoba oil
[0042] 12.0% beeswax
[0043] 2.0% Lecithin
[0044]20.0% talc
[0045] 5.0% Green Tea Polyphenol Extract (70% Polyphenols)
[0046] 0.2% sorbic acid
[0047] 2.0% Ascorbyl Palmitate (Vitamin C)
[0048] 0.2% lavender oil
[0049] 0.1% tea tree oil
[0050] It is necessary to pulverize the polyphenols and the combined carrier until uniform in the preparation process. The polyphenol / carrier is then added to the remainder of the dry mixture upon further mixing and / or milling to obtain a uniformly distributed topical mixture.
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Abstract
The present invention discloses a composition of matter, and method to formulate same, which is an anhydrous topical cream, gel or ointment base, a polyphenol and a suitable adsorbent binding carrier to which the polyphenol will bind for purposes of even disbursement within the cream, gel or base and which will not inhibit the ability of the polyphenols to be released on and into the aqueous environment of the skin when the topical mixture is applied thereto. The binding carrier provides the ability to disperse a hydrophilic polyphenol in a non-aqueous medium for purposes of topical application to the body. In particular, the present invention discloses the use of polyphenols such as tea catechins, and in particular green tea catechins, disbursed in an anhydrous base consisting of either saturated or unsaturated plant oils or waxes through the use of a variety of binding carriers including, but is not limited to, talcs and clays, alginates, algae, agars, gums, gelatins, celluloses, silica, silica gels, simethicone, salicylates, silicates and silicone resins, tragacanths, calcium carbonates and magnesium or zinc oxides. Such binding carriers are particularly useful when polyphenol concentrations exceed 0.2% w / w in the mixture, and their use is preferred when concentrations are between 1.0 to 20% w / w polyphenols.
Description
Background of the invention [0001] Plant polyphenols are known to be potent antioxidants and are considered important components of a healthy diet. Increasingly, polyphenols derived from tea, grapes and other plant sources are purified and may be considered dietary supplements for additional beneficial effects. It has begun to be recognized that polyphenols can be applied topically to the skin and confer the same topical beneficial effects on the skin and surrounding tissues. [0002] However, many polyphenols, especially green tea catechins, are very unstable at room temperature and oxidize and decompose within days, especially in the presence of water (1). To ensure the stability of the polyphenols in the topical mixture, the mixture can be formulated without water (anhydrous), thereby increasing the stability of the polyphenols. Other antioxidants such as Vitamin C will add to this stabilizing effect. Saturated or unsaturated vegetable oils are commonly used as bases in ...
Claims
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Application Information
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