Notoginseng hemostatic and its preparing method

The technology of Panax notoginseng and medicine is applied in the field of Panax notoginseng hemostatic drugs and preparation thereof, and can solve the problems of rapid exertion of adverse drug effects, influence on drug quality, and restrictions on promotion, and achieves high bioavailability of human body, simple and easy production operation, Guarantee the effect of production quality

Active Publication Date: 2006-11-08
四川泰华堂制药有限公司
View PDF0 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] (1) The sugar-coated tablet has a lot of dust in the preparation process, which is more harmful to the pharmaceutical production personnel; (2) The sugar-coated tablet has many processes in the production process, which lasts 48 to 72 hours, and the operating conditions are not easy to master, and the thickness of the isolation layer is easy to be uneven. Mottling, cracking, moisture absorption and other phenomena are prone to appear during the placement process, which affects the quality of the drug; (3) The disintegration time of sugar-coated tablets is 1 hour, and the dissolution time will increase with the prolongation of storage time; (4) Sugar-coated tablets The quality standard of the tablet is not perfect enough, and only the identification test is carried out on the finished product

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0050] Example 1: Preparation of Sanqi Hemostatic Capsules

[0051] Obtain 85 parts of land weeds and 15 parts of Panax notoginseng.

[0052] Preparation of medicinal material extract: pulverize Panax notoginseng into a fine powder of 120 meshes, and decoct and extract two times with water according to the conventional method. The amount of water added for each time is 10 times the amount of crude drug, the first time is 2 hours, the second time is 1 After hours, combine the decoction, filter, and concentrate the filtrate to a thick paste with a relative density of 1.25 at 60°C, add panax notoginseng powder, dry at 60°C, pulverize the dry paste into fine powder, add 4% starch, 10% micronized silica gel , Mix well, get the powder, set aside.

[0053] Capsule preparation: Take the above-mentioned medicinal powder and fill hard hollow capsules to obtain the medicine of the present invention. Each capsule weighs 0.25 g.

Example Embodiment

[0054] Example 2: Preparation of Sanqi Hemostatic Capsule

[0055] Take 96 parts of celestial herb and 4 parts of Panax notoginseng.

[0056]Preparation of medicinal material extract: Take Panax notoginseng to superfinely pulverize into micronized powder, add water and microwave for extraction twice, each time adding water is 8 times the amount of crude drug, each time for 0.5 hours, combine the extracts, filter, the filtrate has large holes Adsorption resin adsorption, wash with 5 times the amount of water to remove impurities, eluted with 4 times the amount of 70% ethanol, collect the eluate, recover the ethanol until there is no alcohol smell, and concentrate to a thick paste with a relative density of 1.25 at 60°C. Add Panax notoginseng powder, dried below 60℃, dry paste pulverized with 100 mesh fine powder, add 40% microcrystalline cellulose, 2% talc, and mix well to obtain powder for use;

[0057] Capsule preparation: Take the above-mentioned medicinal powder and fill hard h...

Example Embodiment

[0058] Example 3: Preparation of Sanqi Hemostatic Capsule

[0059] Take 95 parts of celestial herb and 5 parts of Panax notoginseng.

[0060] Preparation of medicinal material extract: Take Panax notoginseng and pulverize it into 120 mesh fine powder, add water and decoction for two times, adding water for each time 8 times the amount of crude drug, the first time is 2 hours, the second time is 1 hour, and the extracts are combined , Filter, the filtrate is adsorbed on the macroporous adsorption resin, washed with 5 times the amount of water to remove impurities, eluted with 4 times the amount of 50% ethanol, collect the eluate, recover the ethanol until there is no alcohol smell, and concentrate to the relative temperature at 60 ℃ For thick paste with density of 1.25, add panax notoginseng powder, dry below 60℃, smash the dry paste, add 20% dextrin, 2% magnesium stearate, and mix well to obtain powder for use;

[0061] Capsule preparation: Take the above-mentioned medicinal powde...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention discloses a kind of notoginseng hemostatic for stopping bleeding and killing pain and its preparation process. The notoginseng hemostatic is prepared with notoginseng and wolfs milk as main material, and through extraction to form extractum, crushing, adding stuffing and lubricant, and encapsulating. It has the features of easy disintegration, fast absorption, high bioavailability and high curative effect.

Description

[technical field] [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and in particular relates to a notoginseng hemostatic medicine and a preparation method thereof. [Background technique] [0002] Radix Notoginseng hemostatic drug has the effects of promoting blood stasis and hemostasis, reducing swelling and relieving pain, etc. It is used for vomiting blood, epistaxis, bloody dysentery and metrorrhagia, postpartum bleeding, menorrhagia and traumatic bleeding. Existing commercially available Panax notoginseng hemostatic tablets use a large amount of sucrose and talcum powder in the coating, which has high production intensity and is easily polluted. Although talc powder is a legal pharmaceutical excipient, heavy metals can also be introduced due to its use, and the disintegration release is relatively low. Slow, the taste is poor. [0003] In Volume 11 of "Prescriptions of Traditional Chinese Medicine", it is recorded that a prescription i...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K36/47A61K9/48A61P7/04
Inventor 俞凯
Owner 四川泰华堂制药有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap