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Suspension of loteprednol etabonate and tobramycin for topical ophthalmic use

A technology of tobramycin and loteprednol, which is applied in the direction of anti-inflammatory agents, non-central analgesics, medical preparations containing active ingredients, etc., and can solve the problems of not showing drug activity

Inactive Publication Date: 2007-01-17
BAUSCH & LOMB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these buffers are useful for stabilizing pH, they do not exhibit pharmaceutical activity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Ingredients (per ml)

[0039] Loteprednol 0.5% (5mg)

[0040] Glycerin 2.5%

[0041] Polyvinylpyrrolidone, K-90 0.6%

[0042] Tobramycin 0.3% (3mg)

[0043] Benzalkonium Chloride 0.01%

[0044] Tyloxapol 0.05%

[0045] Disodium EDTA 0.01%

[0046] Purified water (full to 100%)

[0047] Sulfuric acid or sodium hydroxide (for pH adjustment)

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PUM

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Abstract

This invention relates to formulations for topical use comprising antibiotics in combination with anti-inflammatory steroids for treating ophthalmic infections and attendant inflammation. More specifically, this invention relates to pharmaceutical ophthalmic formulations comprising a pH stabilizing amount of tobramycin and the soft steroid loteprednol etabonate.

Description

technical field [0001] The present invention relates to topical formulations for the treatment of ocular infections and associated inflammation comprising antibiotics and anti-inflammatory steroids. More specifically, the present invention relates to pharmaceutical ophthalmic formulations comprising pH-stabilized amounts of tobramycin and the soft steroid loteprednol. Background technique [0002] Topical steroids (eg, corticosteroids) are commonly used in the anti-inflammatory treatment of the eye, particularly for the treatment of inflammation of the eyelids or bulbar conjunctiva, cornea and anterior segment of the eye. Routine therapeutic use of steroids includes allergic conjunctivitis, rosacea, superficial punctate keratitis, and iritis cyclitis. Steroids are also used to ameliorate inflammation associated with corneal injury due to chemical burns, thermal burns, or foreign body penetration. These conditions can result from eye surgery, injury, allergies, or infection...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/56A61K31/7036A61K9/00A61K31/14A61K31/573A61K31/704
CPCA61K31/7036A61K9/0048A61K31/704A61K9/0043A61K31/14A61K31/573A61K31/56A61P27/02A61P27/16A61P29/00A61P31/04Y02A50/30A61K2300/00A61K31/7028
Inventor 拉梅什·克里什纳穆尔蒂
Owner BAUSCH & LOMB INC