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Microsphere of two anti-tubercular drugs and a biodegradable polymer administered by inhalation alone or combined with oral route, and process thereof

A technology for degrading polymers and anti-tuberculosis drugs, which can be used in drug delivery, pharmaceutical formulations, active ingredients of heterocyclic compounds, etc., and can solve problems such as reducing treatment dose and frequency or duration

Inactive Publication Date: 2007-01-24
COUNCIL OF SCI & IND RES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] Furthermore, this makes it possible to reduce the dose and frequency or duration of treatment

Method used

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  • Microsphere of two anti-tubercular drugs and a biodegradable polymer administered by inhalation alone or combined with oral route, and process thereof
  • Microsphere of two anti-tubercular drugs and a biodegradable polymer administered by inhalation alone or combined with oral route, and process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] In vivo studies on mice:

[0080] Microparticle / drug solution preparation

[0081] a. Rifabutin + isoniazid particles

[0082] The microparticles described above were prepared as previously described. Particle size analysis of the microparticles showed that 90% of the particles were below 10 microns in size.

[0083] b. Rifabutin solution

[0084] Rifabutin solutions for oral administration were prepared in water containing 10% DMSO.

[0085] c. Isoniazid solution

[0086] A solution of isoniazid for oral administration is prepared in water.

[0087] Infection & Treatment:

[0088] Swiss albino mice weighing 18-22 g at the age of 4-6 weeks were used for the study. Intravenous route with 10 7 CFUs / 0.2mL of Mycobacterium tuberculosis H 37 R v strains to infect the mice. All infected mice were divided into 8 groups of six mice each. Infected mice were treated 24 hours post-infection with the following drug formulations:

[0089] Group 1 - inhaled rifabutin + i...

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Abstract

The present invention relates to a biodegradable microparticle composition useful for the target specific drug delivery to manage pulmonary tuberculosis, said composition comprising two anti-tuberculosis drugs, and a biodegradable polymer for drug delivery in a ratio of about 1:2 to 2:1, wherein the anti - tubercular drugs are in the ratio of 1:2 to 2:1, also, a process for the preparation of the composition, and lastly, a method of treating pulmonary tuberculosis in a subject, said method comprising administering by inhalation alone or in combination with oral route, pharmaceutically effective amount of the composition to the subject in need thereof, wherein the dosage for inhalation is ranging between 0.5 to 10 mg / kg body weight / day and that for oral route is ranging between 4 to 32 mg / kg body weight / day.

Description

technical field [0001] The present invention relates to a biodegradable microparticle composition for target-specific drug delivery for the treatment of pulmonary tuberculosis, said composition comprising two anti-tuberculosis drugs and biological agents for drug delivery in an approximate ratio of 1:2-2:1 The degradable polymer, wherein the ratio of the anti-tuberculosis drugs is 1:2-2:1. In addition, the invention also relates to a method for the preparation of the composition. Finally, the present invention relates to a method of treating pulmonary tuberculosis in an individual comprising administering to the individual in need of treatment a pharmaceutically effective amount of said composition by inhalation alone or in combination with the oral route, wherein the dose for inhalation is 0.5 - 10 mg / kg body weight / day, and the dose for oral route is 4-32 mg / kg body weight / day. technical background [0002] Most infectious diseases are caused by parasitic microorganisms ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/00A61K31/455A61K31/445
Inventor 海玛德瑞·森苏雅库玛·翟岩丝瑞克实·森哈劳丽·沙玛帕婉·姆提尔
Owner COUNCIL OF SCI & IND RES
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