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Combinatorial therapy with an acetylcholinesterase inhibitor and (3AR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3,-b]indol-5-yl phenylcarbamate

A technology of acetylcholinesterase and tolylhydroxyalanine, which is applied in the direction of drug combinations, medical preparations containing active ingredients, ester active ingredients, etc., can solve the problems of increasing drug production costs

Inactive Publication Date: 2007-02-28
AXONYX INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This separation of enantiomers greatly increases the cost of drug production

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  • Combinatorial therapy with an acetylcholinesterase inhibitor and (3AR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3,-b]indol-5-yl phenylcarbamate
  • Combinatorial therapy with an acetylcholinesterase inhibitor and (3AR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3,-b]indol-5-yl phenylcarbamate
  • Combinatorial therapy with an acetylcholinesterase inhibitor and (3AR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3,-b]indol-5-yl phenylcarbamate

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[0001] Relevant references to said application

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Abstract

The present invention relates to an improved method of treating, reducing or delaying cognitive impairments associated with the beta-amyloid peptide, either in combination with treatment by cholinomimetic replacement therapy or as a prophylactic treatment.

Description

[0001] Relevant references to said application [0002] This application claims priority to US Patent No. 60 / 545,046, filed February 17, 2004, the entire contents of which are incorporated herein by reference. technical field [0003] The present invention relates generally to biotechnology and, more particularly, to various methods and compounds useful in the treatment of cognitive disorders. Background technique [0004] Since it was revealed that defects in the cholinergic system lead to cognitive impairment associated with normal aging and Alzheimer's disease (AD) (Bartus et al., Science 217:408-417 (1982); Fischer et al., Neurobiol. Aging 13 : 9-23(1992)), more research has focused on the development of cholinomimetic replacement therapy as a potential therapy for these injuries. In these studies, cholinesterase inhibitors, such as physostigmine (Phy) and tetrahydroaminoacridine (THA), have been studied for memory-enhancing effects in both animal and human subjects (Ru...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/40C07D487/04A61K31/27A61K31/662A61K31/407A61K31/445A61K31/45A61K31/473A61K31/55A61P25/28A61P43/00
CPCA61K31/45A61K31/445A61K31/473A61K31/407A61K31/55A61P25/28A61P43/00
Inventor 戈斯·布鲁因斯马
Owner AXONYX INC