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Methods of preventing weight gain

A technology for food intake and medicine, applied in the direction of active ingredients of heterocyclic compounds, etc.

Inactive Publication Date: 2007-03-21
MOR RES APPL LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0024] The present invention provides the use of H 1 This type of approach to receptor agonists successfully addresses the deficiencies of currently known methods for regulating food intake, the H 1 Receptor agonists are highly potent in humans and have a pharmacological half-life of at least 3 hours without the limitations of currently known methods

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0240] The following studies were performed in order to evaluate the effect of oral administration of betahistine on food intake:

[0241] Recruit 10 obese but healthy people. Their characteristics at the time of recruitment are shown in Table 1. Exclusion criteria in this study were age below 18 years, active disease, use of medications, known hypersensitivity or contraindications to betahistine.

[0242] Each subject was randomized to receive betahistine 16 mg or placebo at 10:00 and 16:00. Intraday body weight, caloric intake (24-hour recall) and appetite (VAS, visual analogue scale) were obtained on days 0, 14 and 28 of the study. Subjects are assigned to eat and drink according to their appetite without restriction.

[0243] Statistical significance was assessed using a t-test. BMI means body mass index.

[0244] Table 1. Patient Characteristics

treat

age

weight(kg)

BMI

Average caloric intake (kcal)

Average Appetite Score (V...

Embodiment 2

[0261] On another day, healthy overweight women were treated with 16 mg betahistine twice daily for 1 month without any dietary changes. As observed in the blood tests, certain metabolite levels were determined in this woman before and after betahistine treatment and are listed in Table 2 below.

[0262] day 0

[0263] As observed in Table 2, the results indicate that the total cholesterol level of the individual decreased with a corresponding decrease in LDL-cholesterol level and an increase in HDL-cholesterol level during the studied 30-day time period. Triglyceride levels decreased, while fructosamine levels increased very slightly. It was therefore concluded that individuals restricted their fat intake (as evidenced by lowering of LDL-cholesterol) without reducing their carbohydrate intake (as evidenced by a slight increase in fructosesamine levels), indicating that betahistine is effective in reducing the Fat intake has specific effects.

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Abstract

Methods for regulating food intake in a human subject; for improving a compliance of a human subject to caloric restriction; and for reducing a desire of a human subject to consume fats, utilizing H1-receptor agonists that have a pharmacological half-life that allows an efficient treatment regime thereof are disclosed. The methods can be efficiently used for treating conditions such as overeating, overweight, obesity, binge eating disorder, night eating syndrome, obsessive eating, compulsive eating and bulimia, as well as conditions associated with metabolic derangement such as dyslipidemia.

Description

field of invention [0001] The present invention relates to novel methods of regulating food intake in human subjects, and more particularly, the present invention relates to methods of preventing or treating diseases in which weight control is beneficial. Background of the invention [0002] Obesity is a chronic, complex multifactorial disease that includes social, cultural, genetic physiological and psychological components and is associated with substantially increased morbidity and mortality. Approximately 400,000 deaths per year in the USA can be attributed to overnutrition (Mokdad, 2004) and can be considered an epidemic. Based on body mass index (BMI), defined as the ratio of weight to height squared (usually in the range 18.5-24.9), approximately one-third of the adult population is overweight (index 25-29.9) and more than one-quarter is obese ( index greater than 30) (National Center for Health Statistics, 2000). Environmental and behavioral changes resulting in ec...

Claims

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Application Information

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IPC IPC(8): A61K31/445A61K31/44C07D
Inventor N·巴拉克
Owner MOR RES APPL LTD
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