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Angiogenesis-affecting compounds and methods of use thereof

An angiogenesis and compound technology, applied in the directions of active ingredients of heterocyclic compounds, medical preparations containing active ingredients, cardiovascular system diseases, etc., can solve problems such as liver damage

Inactive Publication Date: 2007-03-28
ANGIOGENETICS SWEDEN AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Flutam has been used successfully to suppress androgens, however, there is a serious and real risk of liver injury associated with its use

Method used

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  • Angiogenesis-affecting compounds and methods of use thereof
  • Angiogenesis-affecting compounds and methods of use thereof
  • Angiogenesis-affecting compounds and methods of use thereof

Examples

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Embodiment Construction

[0071] The following examples are only used to illustrate the present invention, but not for the purpose of limiting the present invention. If the source is not specified, the material is known and commercially available.

[0072] It is to be understood that, as a result of their manufacture and use, the compounds of the present invention can have chemical and structural properties that differ from those listed below. For example, during use, compounds may undergo a series of metabolic changes that produce intermediates whose characteristics may not fall within certain parameters enumerated below. However, such intermediates and metabolic end products are still within the scope of the present invention if they have the requisite values ​​specified hereinafter before, during or after administration.

[0073] As indicated above, the compounds of the invention may be used to affect angiogenesis. Such use may be limited to cell or tissue culture applications, as well as administ...

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PUM

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Abstract

Angiogenesis may be affected by administering a compound to a group of cells, a tissue or an organism. Such affect may be to inhibit or stimulate angiogenesis. The compounds may be used to treat disease states related to insufficient or unregulated angiogenesis.

Description

technical field [0001] The present invention relates to compounds useful for promoting or inhibiting angiogenesis and to pharmaceutical compositions containing compounds affecting angiogenesis, which are useful in a variety of diseases associated with angiogenesis. The invention further relates to methods of use of such angiogenesis-affecting compounds. Background technique [0002] Angiogenesis is the fundamental process of forming new blood vessels. This process involves the migration of blood vessel endothelial cells into the tissue, and these endothelial cells then aggregate into blood vessels. Angiogenesis can be induced by angiogenic agents or the result of natural conditions. Angiogenesis or its lack plays an important role in a variety of pathological conditions. Some of these states are characterized by neovascularization, eg, cancer, diabetic retinopathy, glaucoma, and age-related macular degeneration. Others, such as stroke, infertility, heart disease, ulcers ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4402A61K39/395A61P35/00A61P17/06A61K31/445A61K31/7048A61K45/06
CPCA61K31/4402A61K45/06A61K39/3955A61K31/7048A61K31/445A61P1/04A61P9/00A61P9/04A61P9/10A61P17/02A61P17/06A61P25/00A61P27/02A61P29/00A61P35/00A61P43/00A61K2300/00
Inventor 赫尔穆特·奥古斯丁马茨·赫尔斯特勒默
Owner ANGIOGENETICS SWEDEN AB