Dispersing tablets for clearing heat,purging fire and detoxifying

A detoxification function, heat-clearing and fire-clearing technology, applied to medical preparations containing active ingredients, plant/algae/fungus/moss ingredients, plant raw materials, etc., can solve the problem of high proportion content, difficult industrialization, and disintegration of traditional Chinese medicine dispersible tablets It is difficult to control the speed and other problems, so as to achieve the effect of improving disintegration and large room for maneuver

Inactive Publication Date: 2012-03-28
JIANGXI HERBFINE HI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] To sum up, most Chinese medicine dispersible tablets are difficult to control the disintegration speed of Chinese medicine dispersible tablets within 3 minutes due to (1) the high proportion of main ingredients of traditional Chinese medicine, and (2) the adhesion of macromolecular substances such as pectin and polysaccharides. It is more difficult to industrialize than western medicine dispersible tablets
There are many types of industrialized Western medicine dispersible tablets, but there are very few industrialized Chinese medicine dispersible tablets.

Method used

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  • Dispersing tablets for clearing heat,purging fire and detoxifying

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] The traditional Chinese medicine raw materials of Yiqing Dispersible Tablets: Coptis 165 grams, Rhubarb 500 grams, Scutellaria baicalensis 250 grams.

[0055] The weight percentage of traditional Chinese medicine extract and auxiliary materials of Yiqing dispersible tablet: fine powder of Yiqing extract 24%, low-substituted hydroxypropyl cellulose 22%, sodium carboxymethyl starch 18%, microcrystalline cellulose 10%, lactose 20%, Polyvinylpyrrolidone 3%, Magnesium Stearate 3%.

[0056] Yiqing Dispersible Tablets are obtained according to the following specific steps: Coptidis rhizome, rhubarb, and scutellaria baicalensis, and the above three flavors are decocted twice with water, the first time is 1.5 hours, the second time is 1 hour, the decoctions are combined, filtered, and the filtrate is concentrated under reduced pressure to The relative density is about 1.25 (70°C), spray-dried and crushed to obtain a fine powder of Yiqing extract.

[0057] First pass the above-m...

Embodiment 2

[0059] Yiqing extract powder 30% by weight, sodium carboxymethylcellulose 20%, microcrystalline cellulose 12%, cross-linked polyvinylpyrrolidone 16%, polyvinylpyrrolidone 5%, lactose 10%, polyvinylpyrrolidone 4%, micronized silica gel 1%, magnesium lauryl sulfate 2%. All the other are with embodiment 1.

Embodiment 3

[0061] Yiqing extract powder 36% by weight, sodium carboxymethyl starch 20%, croscarmellose sodium 15%, crospovidone 6%, low-substituted hydroxypropyl cellulose 5%, Mannitol 7%, polyvinylpyrrolidone 7%, micronized silica gel 2%, magnesium stearate 1%, HLB=15-16 sucrose fatty acid ester 1%. Sucrose fatty acid ester is P-1570 or P-1670 or LWA-1570, all the other are the same as embodiment 1.

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Abstract

An Yiqing dispersing tablet for treating sore throat, gingivitis, constipation, pharyngitis, tonsillitis, and various types of hemorrhage is prepared from coptis root, rhubarb and scutellaria root.

Description

technical field [0001] The invention relates to the technical field of Chinese patent medicine dispersible tablets, in particular to a clear dispersible tablet. Background technique [0002] Dispersible tablets are a new drug dosage form developed in recent years. Yiqing has many dosage forms, and one of the original dosage forms, Yiqingwei Granules, has been listed in the Chinese Pharmacopoeia (2000 edition). The dissolution of Yiqing granules is slow, the absorption is poor, and the bioavailability is not high. [0003] Compared with ordinary tablets, dispersible tablets require that the temperature of the disintegration medium is 20±1°C, the disintegration time limit is less than 3 minutes, and all the disintegrated particles should pass through the No. 2 sieve. The drug has the advantages of rapid dissolution, fast absorption, high bioavailability, and convenient administration. It can be swallowed, chewed, sucked or dispersed with water. It is especially suitable for t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/708A61K36/718A61K36/481A61K9/20A61P11/04A61P1/02A61P1/10A61P7/04
Inventor 罗晓健王跃生吕爱平饶毅王金钱游剑张爱玲
Owner JIANGXI HERBFINE HI TECH
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