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Platelet biomarkers for the detection of disease

A biomarker, platelet technology, applied to these same tumours, could solve the problem of not providing a reliable indication of angiogenic activity.

Inactive Publication Date: 2007-06-06
CHILDRENS MEDICAL CENT CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, current methods for measuring the levels of angiogenic growth factors to detect said modulators do not provide a reliable indication of angiogenic activity

Method used

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  • Platelet biomarkers for the detection of disease
  • Platelet biomarkers for the detection of disease
  • Platelet biomarkers for the detection of disease

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Experimental program
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Embodiment

[0209]Circulating platelets contain a variety of regulators capable of modifying the angiogenic process. The ability of platelets to attach to abnormal surfaces and release their contents in the local environment makes them a highly desirable form of local angiogenic factor delivery. In physiological conditions of angiogenesis, this strictly local release of growth factors represents a highly flexible, safe and efficient system for wound healing or regeneration; but in pathological conditions, such as in cancer, chronic inflammatory disorders or vascular abnormalities , which represents a critical paracrine amplification loop for growth.

[0210] Platelets have a number of mechanisms for this controlled, highly ordered and locally reactive activity:

i) Platelet microparticles (PMPs) are shed during tumor progression: tumor vasculature is known to activate platelets, mainly because of its open and highly irregular endothelial cell surface; PMPs containing VEGF, bFGF and other...

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Abstract

The present inventors have surprisingly discovered that platelets sequester angiogenic regulators and prevent their degradation. Thus, by analyzing levels of angiogenic regulators in platelets, it is now possible to detect angiogenic activity, even at an early stage. By monitoring for changes in angiogenic activity, the presence of cancer or other angiogenic diseases or disorders can be predicted.

Description

[0001] Cross-references to related applications [0002] The application requires U.S. Provisional Application Serial No. 60 / 565,286, the U.S. Provisional Application Serial No. 60 / 565 submitted on August 2nd, 2004 on April 26th, 2004 under 35U.S.C.§119 (e) of the U.S. 598,387, U.S. Provisional Application Serial No. 60 / 609,692, filed September 13, 2004, U.S. Provisional Application Serial No. 60 / 633,027, filed December 3, 2004, and U.S. Provisional Application Serial No., filed December 6, 2004 Priority of 60 / 633,613, which is hereby incorporated by reference in its entirety. Background of the invention [0003] [002] Angiogenesis is the process of vascularization of tissue, involving the growth of new blood vessels into tissue, and is also referred to as neovascularization. Blood vessels are the pathways by which oxygen and nutrients are supplied to, and waste products are removed from, living tissue. When appropriate, angiogenesis is a key biological process. For example...

Claims

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Application Information

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IPC IPC(8): C12Q1/00
CPCG01N2800/52
Inventor J·福尔克曼G·克莱门特
Owner CHILDRENS MEDICAL CENT CORP