Sustained-release preparation of nicorandil

Abstract

The invention relates to a slow-release agent of Nicotie and relative production, wherein it uses Nicotie as material, adds slow-release skeleton material and drug to obtain solid disperser; releases the drug to hold blood density. The invention can reduce feeding time, reduce blood peak-valley condition, improve safety and reduce drug consumption.

Description

[0001] [Technical Field] The present invention relates to a sustained-release preparation of nicorandil and a preparation method thereof. [Background technique]

[0002] The research and development of sustained-release preparations has a history of more than 40 years. It releases slowly and at a non-constant rate as required in a prescribed environment. Prolonged formulation. This kind of preparation can make the human body maintain this kind of blood drug concentration for a long time, instead of dropping rapidly like ordinary preparations, so as to avoid the "peak and valley" phenomenon that occurs when common preparations are frequently administered, and ensure the safety of the drug. Sexuality, effectiveness or adaptability have been improved, thereby reducing the number of medications, which greatly facilitates patients, especially patients who have been taking medication for a long time. Commonly used oral dosage forms include matrix tablets, microporous coated surface...