Magnetic nano particle compound for nucleic acid separation and its preparation method and uses

A technology for separation of magnetic nanoparticles and nucleic acids, applied in the field of nanomaterials in the field of biotechnology, can solve problems such as small particle surface area, and achieve the effects of simple operation, easy control of shape and diameter
CN1995052AInactive Publication Date: 2007-07-11上海柏汇申生物科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
上海柏汇申生物科技有限公司
Publication Date
2007-07-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a magnetic nanometer particle compound and making method and application to separate nucleic acid especially mRNA, which comprises the following three layers: (1) inner nuclear layer with magnetic nanometer particle with superparamagnetism, (2) biological inert outer layer to clad inner nuclear layer, (3) decorating layer with affinity or antibiotin on the surface of outer layer.
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Description

technical field

[0001] The invention belongs to the field of nanometer materials, and more specifically relates to nanomaterials applied in the field of biotechnology. Background technique

[0002] Nucleic acid extraction, especially mRNA extraction technology is not only an important part of molecular biology technology, but also an important basis for functional genomics research technology. With the advent of the post-genome era, seeking an effective method for extracting nucleic acid, especially mRNA, has become an urgent problem to be solved. mRNA is messenger ribonucleic acid (messenger RNA). It is a messenger, or template, that exists in biological cells to transfer genetic information from DNA to functional proteins. It has become a research hotspot to elucidate the function of genes and the regulation mechanism of gene expression by studying gene expression profiling analysis. However, one of the biggest challenges in gene expression profiling is the extraction a...

Claims

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