Biomarkers for diagnosing implant related risk of implant revision due to aseptic loosening

a biomarker and implant technology, applied in the field of implant related risk of revision, can solve the problems of difficult revision replacement, progressive bone destruction, and difficult revisions in the lifetime of younger patients

Active Publication Date: 2022-08-02
LYFSTONE BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0013]The present inventors have solved this need by having identified biomarkers, and in particular calprotectin, S100A8 and S100A9, which allow early stage diagnosis of implant loosening, even in asymptomatic patients.

Problems solved by technology

Yet despite its success as a surgical procedure, THA is still considered a treatment of last resort because it requires excision of the entire femoral head.
It is this major alteration of the femur that often makes revision replacement difficult.
As a result, younger patients face the prospect of multiple, difficult revisions in their lifetime.
At an early stage, this condition is typically associated with micromovement at the implant-bone interface causing progressive destruction of bone.
Initially, this condition is often painless and because of this symptomless interval the loss of bone stock may be massive before patients seek advice.
By then, the conditions for a revision procedure may be unfavorable and the expected survival time for a new prosthesis is decreased.

Method used

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  • Biomarkers for diagnosing implant related risk of implant revision due to aseptic loosening
  • Biomarkers for diagnosing implant related risk of implant revision due to aseptic loosening
  • Biomarkers for diagnosing implant related risk of implant revision due to aseptic loosening

Examples

Experimental program
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Effect test

example 1

KIT for Measuring Levels of Calprotectin in a Sample

[0200]The CALPROLAB™ Calprotectin ELISA (ALP) is a quantitative assay for measuring Calprotectin in samples. The assay is commercially available.

[0201]Principle of the Test:

[0202]In the ELISA, samples and standards are incubated in separate microtiter wells coated with monoclonal antibodies which bind the Calprotectin. After incubation and washing of the wells, bound Calprotectin is allowed to react with enzyme-labelled, immunoaffinity-purified Calprotectin-specific antibodies. After this reaction, the amount of enzyme bound in the microtiter wells is proportional to the amount of Catprotectin in the sample or standard, which is determined by incubation with a substrate for the enzyme giving a coloured product. The colour intensity is determined by absorbance using an ELISA plate reader, and is proportional with the concentration of Calprotectin in the standards and samples. The assay is calibrated using Catprotectin purified from ...

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PUM

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Abstract

The present invention relates generally to the field of implant related risk of revision, in particular implant related risk of revision not caused by an infection or metal on metal reaction. The present invention provides methods of diagnosing implant related risk of revision, use of kits for such diagnostic purposes and compositions for use in the treatment of implant related risk of revision, in particular implant related risk of revision not caused by an infection or metal on metal reaction.

Description

FIELD OF THE INVENTION[0001]The present invention relates generally to the field of implant related risk of revision, in particular implant related risk of revision not caused by an infection or metal on metal reaction. The present invention provides methods of diagnosing implant related risk of revision, use of kits for such diagnostic purposes and compositions for use in the treatment of implant related risk of revision, in particular implant related risk of revision not caused by an infection or metal on metal reaction.BACKGROUND OF THE INVENTION[0002]Approximately 1.5 million total hip replacement (total hip arthroplasty—THA) operations are carried out world-wide annually. This is likely to increase to approximately 3 million worldwide per annum within the next decade. In addition, other types of implants and joint replacements, such as knee, shoulder, foot, ankle, hand, wrist, elbow, cranio-maxillofacial and dental, are also being used in increasing amounts.[0003]Prostheses for...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): G01N33/53G01N33/68
CPCG01N33/6887G01N2333/4727G01N2800/108G01N2800/52G01N2800/56G01N2800/105G01N33/68
Inventor LIAN, STEINMIKALSEN, JARLEBENDIKSEN, ERICHANSEN, ANDERS EINUNG
Owner LYFSTONE BV
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