Genetically modified tumor-targeted bacteria with reduced virulence

a tumor-targeted, genetically modified technology, applied in the field of salmonella isolation, can solve the problems of toxic consequences for the host, wide-spread infection in the cancer patient, and the inability to directly kill bacteria, so as to improve the safety of tumor-targeted bacteria, reduce the ability to kill, and improve the effect of therapeutic
US20020026655A1Inactive Publication Date: 2002-02-28YALE UNIV +1
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
YALE UNIV
Publication Date
2002-02-28
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention is directed to mutant Salmonella sp. having a genetically modified msbB gene in which the mutant Salmonella is capable of targeting solid tumors. The invention is also directed to Salmonella sp. containing a genetically modified msbB gene as well as an genetic modification in a biosynthetic pathway gene such as the purl gene. The present invention further relates to the therapeutic use of the mutant Salmonella for growth inhibition and / or reduction in volume of solid tumors.
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Description

[0001] This application is a continuation-in-part of application Ser. No. 08 / 926,636, filed Sep. 10, 1997, the entire disclosure of which is incorporated by reference herein in its entirety.1. FIELD OF THE INVENTION

[0002] The present invention is concerned with the isolation of a gene of Salmonella which, when genetically disrupted, reduces both virulence and septic shock caused by this organism and increases sensitivity to agents which promote eradication of the bacteria, e.g., chelating agents. The nucleotide sequence of this gene and the means for its genetic disruption are provided, and examples of the use of tumor-targeted bacteria which possess a disruption in this gene to inhibit growth of cancers, including, but not limited to, melanoma, colon cancer, and other solid tumors are described. The present invention also provides for the genetic disruption of this gene in combination with disruption of an auxotrophic gene.2. BACKGROUND OF THE INVENTION

[0003] Citation or identifica...

Claims

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