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a technology of amyloidogenic disease and amyloid aggregation, which is applied in the field of immunology and medicine, can solve the problem of implausible therapeutic benefits, and achieve the effect of reducing the extent or rate of developmen
Inactive Publication Date: 2005-09-01
JANSSEN ALZHEIMER IMMUNOTHERAPY
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Because EP 526,511's proposed dosage would barely alter the level of endogenous circulating Aβ and because EP 526,511 does not recommend use of an adjuvant, as an immunostimulant, it seems implausible that any therapeutic benefit would result.
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[0161] I. Prophylactic Efficacy of Aβ Against AD
[0162] These examples describe administration of Aβ42 peptide to transgenic mice overexpressing APP with a mutation at position 717 (APP717→F) that predisposes them to develop Alzheimer's-like neuropathology. Production and characteristics of these mice (PDAPP mice) is described in Games et al., Nature, supra. These animals, in their heterozygote form, begin to deposit Aβ at six months of age forward. By fifteen months of age they exhibit levels of Aβ deposition equivalent to that seen in Alzheimer's disease. PDAPP mice were injected with aggregated Aβ42 (aggregated Aβ42) or phosphate buffered saline. Aggregated Aβ42 was chosen because of its ability to induce antibodies to multiple epitopes of Aβ.
[0163] A. Methods
[0164] 1. Source of Mice
[0165] Thirty PDAPP heterogenic female mice were randomly divided into the following groups: 10 mice to be injected with aggregated Aβ42 (one died in transit), 5 mice to be injected with PBS / adjuva...
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Abstract
The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response against an amyloid deposit in the patient. The methods are particularly useful for prophylactic and therapeutic treatment of Alzheimer's disease. In such methods, a suitable agent is Aβ peptide, active fragments thereof or an antibody thereto.
Description
CROSS-REFERENCES TO RELATED APPLICATIONS [0001] This application is a divisional of U.S. application Ser. No. 09 / 724,319, filed Nov. 27, 2000, which is a continuation of U.S. application Ser. No. 09 / 322,289, filed May 28, 1999, which is a continuation-in-part of U.S. application Ser. No. 09 / 201,430, filed Nov. 30, 1998 which claims the benefit under 35 U.S.C. 119(e) of U.S. Application No. 60 / 080,970, filed Apr. 7, 1998, and U.S. Application No. 60 / 067,740, filed Dec. 2, 1997, all of which are incorporated by reference in their entirety for all purposes.TECHNICAL FIELD [0002] The invention resides in the technical fields of immunology and medicine. BACKGROUND OF THE INVENTION [0003] Alzheimer's disease (AD) is a progressive disease resulting in senile dementia. See generally Selkoe, TINS 16, 403-409 (1993); Hardy et al., WO 92 / 13069; Selkoe, J. Neuropathol. Exp. Neurol. 53, 438-447 (1994); Duff et al., Nature 373, 476-477 (1995); Games et al., Nature 373, 523 (1995). Broadly speakin...
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