Collagen/glycosaminoglycan compositions for use as terminally sterilizable matrices

a glycosaminoglycan and composition technology, applied in the field can solve the problems of collagen/gag matrix materials that collagen/gag matrix materials cannot be labeled as sterile, collagen/gag matrix materials cannot be used sub-dermally, etc., to achieve optimal biological performance and increase the cross-link density of collagen and glycosaminoglycan compositions
US20060008905A1Inactive Publication Date: 2006-01-12MATTERN RALPH HEIKO +4
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
MATTERN RALPH HEIKO
Publication Date
2006-01-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

Compositions of cross-linked collagen and a glycosaminoglycan are provided which retain characteristics rendering them useful as tissue engineering matrices or scaffolds following terminal sterilization. Also provided are methods for producing these compositions and terminally sterilized matrices or scaffolds from these compositions as well as methods of using these matrices or scaffolds as tissue engineering devices.
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Description

[0001] This application is a continuation of U.S. application Ser. No. 10 / 002,653, filed Oct. 19, 2001, which is herein incorporated by reference in its entirety.

[0002] This invention was supported in part by funds from the U.S. government (NIH Grant No DK56504-01) and the U.S. government may therefore have certain rights in the invention.FIELD OF THE INVENTION

[0003] The present invention relates to compositions comprising collagen and a glycosaminoglycan (GAG) which are useful in terminally sterilized tissue engineering matrices or scaffolds. Collagen / GAG compositions are easily damaged by conventional sterilization techniques. However, matrices or scaffolds comprising the collagen / GAG compositions of the present invention are resistant to damage from terminal sterilization techniques, retaining their function as structural supports, frameworks for tissue formation, cell contact surfaces and therapeutic delivery systems following sterilization via ionizing radiation such as electr...

Claims

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