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Method and apparatus for automated cellular bioinformatics

a bioinformatics and cell technology, applied in the field of methods and apparatus, can solve the problems of high-trained experimenters demanding and repetitive steps, and many of them require significant amounts of time, so as to improve the visibility and communication of progress, improve the visibility of failures, and improve the visibility of progress

Inactive Publication Date: 2006-03-02
CYTOKINETICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention is an automated system for conducting, monitoring, and validating cell-line-based biological experiments. It includes several subsystems and accessories, such as an image production system, a database system, and a report generator. The system allows users to design experiments, construct assay plates, and analyze images of the experiment. It also helps to validate the results and processes of the experiment. The system includes an information system that tracks system failures, opportunities for improvement, and user feedback. Overall, the system provides a flexible and easy-to-use tool for conducting biological experiments.

Problems solved by technology

Each of these steps is exacting, repetitive, and many of them require significant amounts of time from highly trained experimenters to complete.

Method used

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  • Method and apparatus for automated cellular bioinformatics
  • Method and apparatus for automated cellular bioinformatics
  • Method and apparatus for automated cellular bioinformatics

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Embodiment Construction

[0073] System Overview

[0074] The succeeding discussion centers on one or more preferred embodiments of the present invention, implemented by a number of hardware and software components. It will be understood by those having skill in the art that where the embodiments enumerated herein specify certain commercially available hardware, software, or services, these are by way of example. The principles of the present invention are capable of implementation utilizing a wide variety of hardware, software and service combinations, and these principles specifically contemplate all such embodiments.

[0075] Having reference now to FIG. 1A, a conceptual overview of one specific embodiment of the present invention is presented. The system, 1, comprises two main modules, an automated laboratory experiment manager, 50, sometimes herein referred to as “LabRat” and an automated data analysis manager, 60, sometimes herein referred to as “StatRat”. These major subsystems or modules interact with ot...

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Abstract

An automated system that conducts, monitors, and validates a cell-line-based biological experiment including one or more treatment compounds or other external stimuli. In one preferred embodiment, the system comprises two principal subsystems, and optionally accessory subsystems. A first principal subsystem is an automated laboratory experiment manager for designing the biological experiment, for constructing an assay plate used to conduct the biological experiment, and for managing one or more of the processes that constitute the biological experiment. A second principal subsystem is an automated data analysis manager for analyzing images, for instance produced by the image production system, to detect image data including biological markers and objects, for analyzing the resulting image data to produce biological data, and for analyzing the biological data to produce biological phenotypes and treatment compound signatures.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application is a continuation of and claims priority from U.S. patent application Ser. No. 10 / 467,183, filed Jan. 12, 2004, which was the National Stage of International Application No. PCT / US02 / 05266, filed Feb. 20, 2002, which claims priority under 35 USC §119(e) from U.S. Provisional Patent Application No. 60 / 270,314, filed Feb. 20, 2001. These applications are incorporated herein by reference in their entirety and for all purposes.COPYRIGHT NOTICE [0002] A portion of the disclosure of this patent document contains material that is subject to copyright protection. The copyright owner has no objection to the facsimile reproduction by anyone of the patent document or the patent disclosure, as it appears in the Patent and Trademark Office patent file or records, but otherwise reserves all copyrights whatsoever. FIELD OF THE INVENTION [0003] The present invention relates to computer-automated cellular biological systems. More partic...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): G06K9/46G01N15/02G01N15/10G01N15/14G06F19/00G06K9/00G06T7/00
CPCG01N15/1475G01N2015/0294G01N2015/1006G01N2015/1062G01N2015/1477G06T2207/30024G06K9/00993G06K9/6253G06T7/00G06T7/0012G06K9/00127G06V20/69G06V10/96G06F18/40G01N2015/1024G01N15/1433
Inventor KIROS, ESKINDERLING, PINGMULLER, ROBERT J.VENKAT, RAMESHZINK, WESLEY A.
Owner CYTOKINETICS INC
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