Lipid-regulating agent and use thereof

a lipid-regulating agent and lipid-regulating technology, applied in the field of lipid-regulating agents, can solve the problems of large human health problems, hate corpulence, excess burden on the body, etc., and achieve the effect of preventing or improving the increase or accumulation of lipids

Inactive Publication Date: 2006-12-07
HAYASHIBARA BIOCHEMICAL LAB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0007] The first object of the present invention is to provide a lipid-regulating agent for preventing or improving the increase or the accumulation of lipids, which is taken from foods and beverages or synthesized in a living body, in blood or in tissues and organs in a living body. The second object of the present invention is to provide a composition for regulating the amount of lipids, comprising the lipid-regulating agent.

Problems solved by technology

Among those, adiposis, which is caused by the excess increase of lipids in the living body, is a risk factor of those lifestyle-related diseases and is recognized as a large problem on human health.
Also, women in and / or after adolescence tend to hate the corpulence.
Some of them get out of order of hormone valance and cause critical diseases such as osteoporosis by the diet with wrong methods, causing excess burden on the body.
However, many people are forced to abandon such methods because they require pointed leadings and a long period.
Also, the dietary restriction is not preferable from the viewpoint of mental health.
Although taking drugs is effective for curing or preventing adiposis and hyperlipemia, the side-effect and cost of the drugs cause problems.
However, in the case of using those ingredients for materials of foods and beverages, some of those ingredients are food materials having disadvantages of deteriorating the taste, flavor, and mouthfeel; being not effective without taking in a relatively large amount; or causing diarrhea depending on the physical condition or the predisposition.
However, in all those literatures, there is no disclosure about the lipid-regulating activity of CTS and / or its saccharide-derivative(s) or a composition comprising those saccharides.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

experiment 1

[0028] As disclosed in International Publication No. WO 01 / 090,338, it is known that CTS has a dietary fiber-like activity. Therefore, the present inventors considered that CTS may have some effects on living bodies. They investigated the effect of CTS on the lipid metabolism using rats by administrating a feed comprising a representative dietary fiber, cellulose or non-fiber feed as controls.

experiment 1-1

Feeding Test on Rat and the Measurement of the Weight

[0029] Fifty 5-weeks aged male Wister-rats, having a weight of 110 to 120 grams, commercialized by Charles River Japan, Kanagawa, Japan, were fed on a non-fiber feed having a composition shown in Table 1 for one week for habituation. After the habituation, the rats were randomly divided into five groups and each group was fed on either of feeds shown in Table 1, i.e., a non-fiber feed, a feed in which cellulose was incorporated into the non-fiber feed to give a content of 5% (hereinafter, abbreviated as “fiber feed”), a feed in which powdery anhydrous crystalline CTS (purity of CTS: 99.5%), prepared by the method of Example A-3 described later, was incorporated into the non-fiber feed to give a content of 1, 2, or 5%, on a dry solid basis, and the feeding test was carried out for four weeks. A fiber-feed and three kinds of feeds comprising CTS were prepared to give the total content of cellulose or CTS and corn starch of 44.75% ...

experiment 1-2

Effect of the Administration of a Saccharide Comprising CTS and its Saccharide-Derivatives on the Lipids of Rat

[0042] From the results in Experiment 1-1, it was confirmed that CTS has a lipid-regulating activity for rat. Successively, a test was carried out to confirm that a saccharide comprising CTS and its saccharide-derivatives has the same activity as in the case of CTS only as follows. Further, the amount of bile acids which are known to involve the lipid-regulation and GOT activity which is used as an index of hepatic function disorder were measured. The amount of LDL-cholesterol was measured along with the amount of total cholesterol to investigate that the decline of the amount of cholesterol observed in Experiment 1-1 is caused by decreasing the amount of LDL-cholesterol, which is recognized as a cause of arterial sclerosis and cardiac infarction, or not. A significant difference test was done with respect to the group fed on the fiber feed. In the case of cholesterol, si...

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Abstract

The object of the present invention is to provide a lipid-regulating agent or a composition for regulating the amount of lipids comprising the agent. The present invention solves the above object by providing a lipid-regulating agent comprising a cyclic tetrasaccharide and/or its saccharide-derivative(s) and a composition for regulating the amount of lipids comprising the lipid-regulating agent.

Description

TECHNICAL FIELD [0001] The present invention relates to a novel lipid-regulating agent and use thereof, particularly, to a novel lipid-regulating agent comprising a non-reducing saccharide where four glucose molecules are bound via alternating α-1,3 and α-1,6 linkages, i.e., a cyclic tetrasaccharide, represented by the formula of cyclo {→6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1→6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1→) (hereinafter, simply abbreviated as “CTS” in this specification), and / or its saccharide-derivative(s) as an effective ingredient(s), and to a composition for regulating the amount of lipids, comprising the lipid-regulating agent. BACKGROUND ART [0002] In recent years, accompanying with the progress in living standard, dietary habits have altered to Western-style in many countries including Japan. Therefore, we tend to intake excess calories and lipids compared with a traditional dietary habit. As a result, patients and potential patients of lifestyl...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/724A61K31/7048A61K31/353A23D9/007A61K31/575A61K31/702A61P1/00A61P1/10A61P1/16A61P3/04A61P3/06A61P3/10A61P7/02A61P9/00A61P9/04A61P9/10A61P9/12A61P35/00C07H3/06
CPCA23D9/007A23K1/1643C07H3/06A61K31/702A23L1/30A23K20/163A23L33/10A61P1/00A61P1/10A61P1/16A61P3/10A61P35/00A61P3/04A61P3/06A61P7/02A61P9/00A61P9/04A61P9/10A61P9/12
Inventor OKU, KAZUYUKIKUBOTA, MICHIOFUKUDA, SHIGEHARUMIYAKE, TOSHIO
Owner HAYASHIBARA BIOCHEMICAL LAB INC
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