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Use of a nitroxide or a prodrug thereof in the prophylactic and therapeutic treatment of cancer

a cancer and prophylactic treatment technology, applied in the field of nitroxides and prodrugs thereof, can solve the problems of afflicted suffering physically, emotionally and financially, early death of patients, and major world-wide health problems

Inactive Publication Date: 2007-01-25
GOVERNMENT OF THE USA REPRESENTED BY THE SEC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The present invention provides a method for preventing and treating cancer in mammals, particularly humans, by administering a nitroxide or prodrug thereof to an animal at risk for cancer or with cancer. The nitroxide or prodrug can prevent or treat the cancer by targeting specific molecules or pathways involved in the development of cancer. The nitroxide or prodrug can be administered in various ways, such as through the skin, by injection, or orally. The invention also provides a composition comprising a nitroxide or prodrug for use in cancer treatment."

Problems solved by technology

Cancer is a major world-wide health problem.
Given that the vast majority of human tumors are difficult to treat effectively, those afflicted suffer physically, emotionally and financially and inevitably die an early death.
There is also a tremendous burden on the families and friends of those afflicted as well as on society at large.
Although extensive research around the world has led to advances in cancer treatment, progress has been slow and there is no known cure.

Method used

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  • Use of a nitroxide or a prodrug thereof in the prophylactic and therapeutic treatment of cancer
  • Use of a nitroxide or a prodrug thereof in the prophylactic and therapeutic treatment of cancer
  • Use of a nitroxide or a prodrug thereof in the prophylactic and therapeutic treatment of cancer

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0034] This example demonstrates that administration of a nitroxide to p53− / − mice delays the onset of tumors.

[0035] Male and female p53− / − mice (strain 129 / Sv-Trp5ntml Tyi) were purchased from Jackson Labs (Bar Harbor, Me.). Such animals uniformly die within a few months after birth due to rapid tumor formation and growth. Animals arrived in the laboratory at 7-8 weeks of age, were acclimated for five days and were randomly divided into control (n=8; average weight=24.6 g) and treatment (n=9; average weight=25.0 g) groups. Both groups were allowed food and water ad libitum. The water of the control group was supplemented with sugar (4 g / 100 ml), whereas the water of the treatment group was supplemented with sugar (4 g / 100 ml) and 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (Tempol) to a final concentration of 58 mM. Mice were sacrificed at the first sign of a visible tumor nodule, gross enlargement of the spleen or marked difficulty in breathing. The results are shown in FIG. 1...

example 2

[0036] This example demonstrates that administration of a nitroxide to normal C3H female mice for their entire life-span decreases the incidence of cancer in such mice.

[0037] Female C3H mice were supplied through the Frederick Cancer Research Center-Animal Production, Frederick, Md. Animals were received at 6 weeks of age and were randomly divided into groups (n=20 / group) as follows: Control-1, which received regular food and water; Control-2, which received regular food and water supplemented with sugar (4 g / 100 ml); Tempol / I Year, which received regular food and water supplemented with sugar (4 g / 100 ml) and Tempol to a final concentration of 58 mM for one year, after which they were converted to regular food and water; and Tempol / Entire Life Span, which received regular food and water supplemented with sugar (4 g / 100 ml) and Tempol to a final concentration of 58 mM for their entire life span. All groups were allowed food and water ad libitum. All groups were followed for their e...

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Abstract

The present invention provides a method for the prophylactic and therapeutic treatment of cancer. The method comprises administering to an animal, preferably a mammal, more preferably a human, at risk for developing a cancer or having a cancer a nitroxide or a prodrug thereof, wherein the nitroxide or prodrug thereof preferably is alicyclic or heterocyclic and more preferably is a compound of Formula I or Formula II: in an amount sufficient to prevent or treat said cancer, wherein said cancer is susceptible to prevention or treatment by said nitroxide or prodrug thereof. Also provided is a composition for use in the method.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This patent application is a continuation of copending U.S. patent application Ser. No. 09 / 424,519, which is the national phase of PCT / US98 / 10685, filed May 27, 1998, claiming the benefit of U.S. Provisional Patent Application No. 60 / 047,724, filed May 27, 1997.FIELD OF THE INVENTION [0002] The present invention relates to nitroxides and prodrugs thereof and their use in the prophylactic and therapeutic treatment of cancer. BACKGROUND OF THE INVENTION [0003] Cancer is a major world-wide health problem. Given that the vast majority of human tumors are difficult to treat effectively, those afflicted suffer physically, emotionally and financially and inevitably die an early death. There is also a tremendous burden on the families and friends of those afflicted as well as on society at large. Accordingly, the ability to prevent cancer, delay its onset and / or slow its progression would benefit everyone. [0004] Although extensive research aro...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K38/00A61K48/00A61K31/695A61K31/69A61K31/675A61K31/7056A61K31/445A61K31/426A61K31/421A61K31/40
CPCA61K31/42A61K31/445A61K31/44
Inventor MITCHELL, JAMES B.RUSSO, ANGELOCHERUKURI, MURALI KRISHNADELUCA, ANNE MARIE
Owner GOVERNMENT OF THE USA REPRESENTED BY THE SEC