Benzylisoquinoline derivative- or bisbenzylisoquinoline derivative-containing psychotropic agent, analgesic and/or antiphlogistic, and health food

Abstract

A psychotropic agent, analgesic and / antiinflammatory agent, or health food which is safe even when taken for an extended period of term, comprising as an effective ingredient a benzylisoquinoline derivative represented by general formula (I): or a bisbenzylisoquinoline derivative represented by general formula (II): or a pharmaceutically acceptable salt thereof.

Description

TECHNICAL FIELD [0001] The present invention relates to a psychotropic agent, an analgesic agent and / or an antiinflammatory agent, or a health food which agent or food contains a benzylisoquinoline or bisbenzylisoquinoline derivative derived from lien tzehsin; use of the derivative for the manufacture of a psychotropic agent, an analgesic agent and / or an antiinflammatory agent, or a health food; and a method for preventing or treating a psychiatric disorder, a pain and / or an inflammation. BACKGROUND ART [0002] Psychiatric disorders are steadily increasing, reflecting the recent stressful society. The psychiatric disorders raise a serious social problem as the patients are inadaptable with society, and also an important issue from the viewpoint of medical economy. Drugs that are capable of affecting mental activity and behavior as the principal pharmacological action are called psychotropic drug, which are classified into schizophrenia drugs, mood-stabilizing drugs, antidepressants, ...

AI Technical Summary

Benefits of technology

[0020] An object of the present invention is to provide a psychotropic agent and a health food in which a natural product-derived substance safer even when taken for an extended period of term is used, in particular a psychotropic agent and a health food having an action of preventing and / or alleviating at least one symptom selected from the group consisting of schizophrenia, depression, anxiety disorder, dysthymia, manic state, epilepsy, and sleep disorder, and / or, an action of effectuating sedation.

[0021] Another object of the present invention is to provide an agent and a health food having analgesic action and / or antiinflammatory action in which a natural product-derived substance safer even when taken for an extended period of term is used, in particular an agent and health food having an action of preventing and / or alleviating a pain, and / or, an action of preventing and / or alleviating an inflammation.

[0022] As a result of extensive investigation for a safer substance acting on the central nervous system and a safer substance having analgesic action or antiinflammatory action for the purposes above, the inventors have found a substance which is higher in safety and has psychotropic action and a substance which is higher in safety and has analgesic and antiinflammatory action among the benzylisoquinoline and bisbenzylisoquinoline derivatives extracted from lien tzehsin and thus achieved the present invention.

[0072] The benzylisoquinoline and bisbenzylisoquinoline derivatives derived from lien tzehsin of which the activity was found in the present invention exhibit no toxicity to the living body and can provide safer drugs having preventive and / or therapeutic effects on central nervous system diseases and preventive and / or therapeutic effects on pains and / or inflammations. They can also be used in health foods and health beverages.

[0073] Further, the psychotropic drug according to the present invention is extremely advantageous as it has smaller adverse reactions than conventional drugs and shows activities in a wider range of psychiatric disorders and neurotropic actions.

[0074] Moreover, the agent possessing analgesic action and / or antiinflammatory action according to the present invention is extremely advantageous as it has smaller adverse reactions than conventional drugs and shows activities in a wider range of pains and inflammations.

Problems solved by technology

The psychiatric disorders raise a serious social problem as the patients are inadaptable with society, and also an important issue from the viewpoint of medical economy.

These symptoms often appear in a complicated way.

However, the causes of the sickness are yet to be clearly understood, and the claim that schizophrenia is a single disease is still under a cloud.

Drugs that have an action on the intracerebral dopamine nervous system have been used for treatment of schizophrenia, but also raised problems of extrapyramidal tract disorders (parkinsonian syndromes) as the adverse reactions, i.e., the adverse reactions observed as catalepsy in animal experiment systems.

However, these drugs also carry the problem of side reactions such as motor coordination disorder, induction of catalepsy, and convulsive action induced by strychnine or picrotoxin.

However, it is pointed out that tricyclic or similar cyclic antidepressants cause anticholinergic actions such as dry mouth, eye adjustment disorder (misty vision), constipation, and dysuria, increase in body weight presumably caused by the antihistamic action, adrenolytic actions such as hypotension, dizziness, and stagger, adverse reactions such as cardiotoxic diseases, as well as acute poisoning by excessive intake.

However, a component contained in Saint John's Wort is known to have a serious adverse reaction, photohypersensitivity, and another component a side reaction affecting the kinetics of cyclosporine metabolism in the body.

Narcotic analgesic agents including morphine exhibit a strong analgesic action through opioid receptor in central nervous system but have a problem that they are likely to cause a drug dependence.

However, non-steroidal antiinflammatory agents are prone to frequently cause side effects such as stomach disorders with increasing efficacy.

However, there are no known reports about the pharmacological effects of lien tzehsin components other than those described above.

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