Systems and methods for arteriotomy localization

Abstract

A targeting catheter is used to locate an arteriotomy, such as is formed during a femoral artery catheterization procedure. The targeting catheter includes one or more targeting aids, such as an inflatable balloon or sensor (e.g., Doppler or temperature sensor), to locate the arteriotomy. The targeting aid may be positioned at the arteriotomy. An ultrasonic beacon on the catheter may then be located relative to a therapeutic ultrasonic applicator (e.g., by using acoustic time-of-flight) so that the focus of ultrasonic energy from the applicator can be aligned with the arteriotomy.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application claims the benefit of U.S. Provisional Application No. 60 / 728,783, filed Oct. 20, 2005 and U.S. Provisional Application No. 60 / 808,665, filed May 26, 2006, both of which are incorporated herein by reference in their entirety.BACKGROUND [0002] 1. Field of the Invention [0003] This disclosure relates to systems of methods for locating arteriotomies. In some embodiments, the localization is used for therapeutic targeting (e.g., for targeting of high-intensity focused ultrasound). [0004] 2. Description of the Related Art [0005] Certain medical procedures result in bleeding penetration wounds inside the body, for example via the insertion of devices into blood vessels and / or organs. Representative procedures include arterial and venous catheterization for cardiologic or radiologic interventional procedures, needle biopsy procedures, and minimally invasive surgery. Improved percutaneous catheterization techniques have enabled...

AI Technical Summary

Benefits of technology

[0008] One embodiment described herein includes an arteriotomy targeting catheter having an arteriotomy targeting aid coupled to the catheter and adapted to detect the location of an arteriotomy and one or more beacons coupled to the catheter proximal to the arteriotomy targeting aid. In one embodiment, the arteriotomy targeting aid comprises an inflatable balloon. In one embodiment, the balloon comprises an elastic polymeric material. In one embodiment, the soft elastic polymeric material is selected from the group consisting of one or more of a polyamide, a polyamide blend, a polyethylene, a polyethylene terephthalate, a polyurethane, a polyamide, and a polyamide blend. In one embodiment, the polyamide blend is PBAX. In one embodiment, the durometer of the balloon material is between 20A and 90D. In one embodiment, the durometer of the balloon material is between 80 A and 65 D. In one embodiment, the durometer of the balloon material is 90 A. In one embodiment, the arteriotomy targeting aid comprises a mechanical expansible device. In one embodiment, the arteriotomy targeting aid comprises an arteriotomy locating sensor. In one embodiment, the arteriotomy locating sensor comprises a temperature sensor. In one embodiment, the temperature sensor is a thermistor. In one embodiment, the arteriotomy locating sensor comprises a flow measurement sensor. In one embodiment, the arteriotomy locating sensor comprises an optical sensor. In one embodiment, the arteriotomy locating sensor comprises an impedance sensor. In one embodiment, the arteriotomy locating sensor comprises a Doppler sensor. In one embodiment, the beacon comprises an ultrasonic transmitter. In one embodiment, the beacon comprises a radio frequency transmitter. In one embodiment, the beacon comprises a magnetic field generator.

Problems solved by technology

Certain medical procedures result in bleeding penetration wounds inside the body, for example via the insertion of devices into blood vessels and / or organs.

Several important limitations are associated with the use of standard compression.

The most painful aspects of the catheterization procedure reported by patients are the standard compression procedure and lying immobile for hours.

The aggressive use of anticoagulants and antiplatelet therapies to prevent thrombus formation during catheterization procedures has greatly increased the difficulty of sealing the access site using compression.

Finally, complications occur, the most frequent of which are the formation of hematomas, pseudo-aneurysms, and / or arteriovenous fistulae.

However, these products are invasive, implant foreign materials, require skill and training to use, and can cause major complications.

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