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Transcutaneous analyte sensor

a transcutaneous analyte and sensor technology, applied in the field of systems and methods for measuring analyte in a host, can solve the problems of inability to know the blood glucose value of the patient, incur dangerous side effects, and physiological derangements

Inactive Publication Date: 2007-10-04
DEXCOM
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AI Technical Summary

Problems solved by technology

In the diabetic state, the victim suffers from high blood sugar, which can cause an array of physiological derangements associated with the deterioration of small blood vessels, for example, kidney failure, skin ulcers, or bleeding into the vitreous of the eye.
Conventionally, a person with diabetes carries a self-monitoring blood glucose (SMBG) monitor, which typically requires uncomfortable finger pricking methods.
Unfortunately, such time intervals are so far spread apart that the person with diabetes likely finds out too late of a hyperglycemic or hypoglycemic condition, sometimes incurring dangerous side effects.
It is not only unlikely that a person with diabetes will take a timely SMBG value, it is also likely that he or she will not know if his or her blood glucose value is going up (higher) or down (lower) based on conventional method.
This inhibits the ability to make educated insulin therapy decisions.

Method used

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[0336]FIG. 20A is a graphical representation showing transcutaneous glucose sensor data and corresponding blood glucose values over time in a human. The x-axis represents time, the first y-axis represents current in picoAmps, and the second y-axis represents blood glucose in mg / dL. As depicted on the legend, the small diamond points represent the current measured from the working electrode of a transcutaneous glucose sensor of a preferred embodiment; while the larger points represent blood glucose values of blood withdrawn from a finger stick and analyzed using an in vitro self-monitoring blood glucose meter (SMBG).

[0337] A transcutaneous glucose sensor was built according to the preferred embodiments and implanted in a human host where it remained over a period of time. The graph illustrates approximately 3 days of data obtained by the electronics unit operably connected to the sensor implanted in the human host. Finger-prick blood samples were taken periodically and glucose conce...

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Abstract

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Description

RELATED APPLICATIONS [0001] This application is a continuation of U.S. application Ser. No. 11 / 077,715, filed Mar. 10, 2005, which claims the benefit of U.S. Provisional Application No. 60 / 587,787 filed Jul. 13, 2004; U.S. Provisional Application No. 60 / 587,800 filed Jul. 13, 2004; U.S. Provisional Application No. 60 / 614,683 filed Sep. 30, 2004; and U.S. Provisional Application No. 60 / 614,764 filed Sep. 30, 2004; each of which is incorporated by reference herein in its entirety, and each of which is hereby made a part of this specification.FIELD OF THE INVENTION [0002] The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. BACKGROUND OF THE INVENTION [0003] Diabetes mellitus is a disorder in which the pancreas cannot create sufficient insulin (Type I or insulin dependent) and / or in which insulin is not effective (Typ...

Claims

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Application Information

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IPC IPC(8): A61B5/145
CPCA61B5/0002A61B5/1473A61B5/1411A61B5/14514A61B5/14532A61B5/14546A61B5/14865A61B5/1495A61B5/6833A61B5/6848A61B5/6849A61B2560/0223A61B5/05A61B5/6832A61B5/14503A61B5/14735A61B5/1486A61B5/14A61B5/150022A61M5/1723A61M2005/1585A61M5/14244A61B5/68335Y02A90/10A61B5/0031A61B5/1451A61B2560/063A61B5/0004A61B5/72A61B17/3468A61B5/14507A61B5/6801A61B2017/3492A61B2560/045A61B5/145A61B5/1468A61B2562/18
Inventor BRISTER, MARKNEALE, PAUL V.THROWER, JAMES PATRICKKLINE, DANIEL S.CODD, DANIEL SHAWNSAINT, SEANMASTERSON, STEVE
Owner DEXCOM
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