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Methods and compositions for the treatment and prevention of lung disease

a technology of retinoic acid receptor and composition, applied in the direction of drug composition, biocide, anhydride/acid/halide active ingredients, etc., can solve the problems of insufficient oxygenation, disability and death, and achieve the effect of promoting the growth of alveolar septa and reducing the rate of alveolar destruction

Inactive Publication Date: 2008-05-29
MASSARO DONALD +2
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  • Abstract
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  • Application Information

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Benefits of technology

"The present invention is about methods and compositions for promoting the formation of alveoli in mammalian lung tissue. The invention involves the use of a therapeutic composition that contains a specific retinoid receptor ligand, which is an RARγ agonist and does not have RAR agonist activity at other receptors. The RARγ agonist has specific activity at the RARγ receptor and is not an agonist of the RARβ or RARα receptors. The therapeutic composition can be used alone or in combination with other therapeutically active ingredients, such as other retinoids or RAR-active ligands. The therapeutic effect of the invention is to decrease the rate of alveolar destruction in emphysemic mammals and promote the growth of alveolar septa."

Problems solved by technology

Lack of adequate gas exchange would lead to disability, which could progress to death.
Diseases that result in fewer alveoli therefore are quite serious, and are common causes of inadequate oxygenation and resultant disability and death.

Method used

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  • Methods and compositions for the treatment and prevention of lung disease
  • Methods and compositions for the treatment and prevention of lung disease
  • Methods and compositions for the treatment and prevention of lung disease

Examples

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example 1

Involvement of RAR Receptors in Alveolus Formation

[0038]In most mammals new alveoli are formed postnatally; thus the lung of many newborn mammals is immature, and not merely a smaller version of the adult lung. For example, in humans alveolus formation can continue up to the age of 20.

[0039]The study of alveolus development in newborn mammals, in this case newborn rats, therefore provides an opportunity to study the effect of various agents on alveolus formation. The rate of increase in specific lung volume (expressed as cm3 / 100 g body weight) in rats is greatest within the first 10 days following birth, after which it increases at a less steep rate.

[0040]However, the lung's efficiency is determined not merely by the volume of air that can be contained in the lung, but by the alveolar surface area, which is a function of tissue growth within the lung. Burri, et al., Anat. Rec., 178: 711-730 (1973) and Burri, Anat. Rec., 180: 77-98 (1974) performed extensive studies of the postnatal ...

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Abstract

Methods and compositions for the treatment of lung disease such as emphysema and / or bronchopulmonary dysplasia in a mammal. Also disclosed are methods and compositions promoting the formation of alveolar septa and increasing the gas-exchange surface area of a mammalian lung, and for the prevention and / or treatment of alveolar destruction.

Description

RELATED APPLICATIONS[0001]This application is a divisional of U.S. application Ser. No. 11 / 180,169, filed Jul. 13, 2005, which is a continuation of U.S. application Ser. No. 10 / 305,049, filed Nov. 25, 2002, now abandoned, which is a continuation of U.S. application Ser. No. 09 / 549,226, filed Apr. 13, 2000, now U.S. Pat. No. 6,492,414, issued on Dec. 10, 2002, which claims the benefit of U.S. Provisional Application No. 60 / 129,216, filed Apr. 14, 1999. The entire teachings of the above applications are incorporated herein, by reference.FIELD OF THE INVENTION[0002]This invention concerns the use of isotype-specific retinoic acid receptor (RAR) agonists for the inhibition of alveolar destruction and / or to promote the formation of alveoli in mammalian lung tissue deficient in adequate numbers of functional alveoli.BACKGROUND OF THE INVENTION[0003]Among aerobic animals, the lung functions to provide an interface for the exchange of gases between blood and the atmosphere. The agents of th...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/203A61K31/07A61P11/00A61K31/00A61K31/381
CPCA61K31/00A61K31/381A61K31/203A61K31/07A61P11/00
Inventor MASSARO, DONALDMASSARO, GLORIA DECARLOCHANDRARATNA, ROSHANTHA A.
Owner MASSARO DONALD
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