Methods for treating pustular conditions of the skin

Abstract

The invention is directed to methods for treating pustular conditions of the skin, for example, acne. Such methods utilize novel compositions, including but not limited to extraembryonic cytokine secreting cells (herein referred to as ECS cells), including, but not limited to, amnion-derived multipotent progenitor cells (herein referred to as AMP cells), conditioned media derived therefrom (herein referred to as amnion-derived cellular cytokine solution or ACCS), cell lysates derived therefrom, and cell products derived therefrom, each alone or in combination.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority under 35 USC §119(e) of U.S. Provisional Application No. 60 / 937,231, filed Jun. 26, 2007, the entirety of which is incorporated herein by reference.FIELD OF THE INVENTION[0002]The field of the invention is directed to methods for treating pustular conditions of the skin. Such methods utilize novel compositions, including but not limited to extraembryonic cytokine secreting cells (herein referred to as ECS cells), including, but not limited to, amnion-derived multipotent progenitor cells (herein referred to as AMP cells), conditioned media derived therefrom (herein referred to as amnion-derived cellular cytokine solution or ACCS), cell lysates derived therefrom, and cell products derived therefrom, each alone or in combination.BACKGROUND OF THE INVENTION[0003]Generalized pustular conditions of the skin include pustular psoriasis, Reiter's disease and subcorneal pustular dermatosis. Medications can cause gen...

AI Technical Summary

Benefits of technology

[0013]The compositions described herein have previously been shown to be useful in treating wounds (details are contained in US Publication No. 2006-0222634-A1 and US Publication No. 2007-0231297 A1, which are incorporated herein by reference). In particular, the compositions described herein have been demonstrated to accelerate wound healing in chronic, infected wounds, even though the compositions themselves are not able to reduce bioburden in such infected wounds. Therefore, the compositions described herein may accelerate healing of pustular conditions of the skin faster and with less scarring than other available treatments, and such accelerated healing may be further enhanced when used in combination with antibiotic treatment or other treatment modalities that are able to reduce bioburden that may be present in pustular conditions of the skin. It is an object of the instant invention to provide novel methods for treating pustular conditions of the skin and such methods utilize novel compositions, including but not limited to extraembryonic cytokine secreting cells (herein referred to as ECS cells), including, but not limited to, amnion-derived multipotent progenitor cells (herein referred to as AMP cells), conditioned media derived therefrom (herein referred to as amnion-derived cellular cytokine solution or ACCS), cell lysates derived therefrom, and cell products derived therefrom, each alone and / or in combination with each other and / or with other agents including active and / or inactive agents.

Problems solved by technology

In particular, the compositions described herein have been demonstrated to accelerate wound healing in chronic, infected wounds, even though the compositions themselves are not able to reduce bioburden in such infected wounds.