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Method for treating symptoms of diabetes

a diabetes and symptom technology, applied in the field of diabetes symptom treatment, can solve the problems of increased morbidity and ineffective wound healing

Inactive Publication Date: 2010-10-07
THE TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ineffective healing of wounds is a serious problem in diabetes, contributing to increased morbidity (Reynolds, 1985; Galloway and Shuman, 1963; and Pearl and Kanat, 1988).

Method used

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  • Method for treating symptoms of diabetes
  • Method for treating symptoms of diabetes
  • Method for treating symptoms of diabetes

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Effect test

example 1

Improved Wound Healing in Diabetic Mice by Treatment with the Soluble Receptor for Advanced Glycation Endproducts (sRAGE)

[0038]Defective wound healing in diabetes continues to be an important cause of morbidity in the postoperative period, following trauma, and in the repair of cutaneous lesions. Advanced Glycation Endproducts (AGEs) are the result of nonenzymatic glycation / oxidation of proteins / lipids. Accelerated formation and accumulation of AGEs in tissues of patients with diabetes has been linked, in certain situations, to the development of secondary complications. An important means by which AGEs perturb homeostatic processes is through their interaction with cellular binding sites; the best characterized of these is Receptor for AGE or RAGE, an immunoglobulin superfamily molecule expressed by endothelium, monocytes, and smooth muscle cells, as well as mesangial cells and neurons. AGE engagement of RAGE leads to endothelial activation, with expression of adhesion molecules, e...

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Abstract

The present invention provides a method for treating symptoms of diabetes in a diabetic subject which comprises administering to the subject a therapeutically effective amount of an agent which inhibits binding of advanced glycation endproducts to any receptor for advanced glycation endproducts so as to treat chronic symptoms of diabetes in the subject.

Description

[0001]The invention disclosed herein was made with Government support under Grant Nos. HL21006 and AG00603 from the National Institutes of Health, U.S. Department of Health and Human Services. Accordingly, the U.S. Government has certain rights in this invention.BACKGROUND OF THE INVENTION[0002]Throughout this application, various publications are referenced by author and date. Full citations for these publications may be found listed alphabetically at the end of the specification immediately the claims. The disclosures of these publications in their entireties are hereby incorporated by reference into this application in order to more fully describe the state of the art as known to those skilled therein.[0003]Ineffective healing of wounds is a serious problem in diabetes, contributing to increased morbidity (Reynolds, 1985; Galloway and Shuman, 1963; and Pearl and Kanat, 1988). The reparative response in wound healing is orchestrated by multiple cellular elements which work togethe...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K9/127A61K38/02A61K31/70A61K31/7088A61K39/395A61P3/10A61K45/00A61K38/00A61K38/17A61P3/12A61P9/02A61P15/10A61P17/02A61P25/00A61P27/02A61P29/00C07K14/705C07K16/28
CPCA61K38/00C07K16/2803C07K14/70503A61K38/1709A61P15/10A61P17/02A61P25/00A61P27/02A61P29/00A61P3/12A61P9/02A61P3/10
Inventor STERN, DAVID M.SCHMIDT, ANN MARIE
Owner THE TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK
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