Circulating microrna as a marker for hepatocellular carcinoma

a circulating microrna and hepatocellular carcinoma technology, applied in the direction of instruments, biochemistry apparatus and processes, material analysis, etc., can solve the problems of variable effectiveness of tools, serological studies lacking sensitivity and specificity in patients with small tumors

Inactive Publication Date: 2011-09-15
QUEST DIAGNOSTICS INVESTMENTS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These diagnostic tools have variable effectiveness for early diagnosis of HCC; cross-sectional imaging typically detects only tumors greater than 1 cm in diameter, and serological studies also lack sensitivity and specificity in patients with small tumors.

Method used

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  • Circulating microrna as a marker for hepatocellular carcinoma
  • Circulating microrna as a marker for hepatocellular carcinoma

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[0092]The present methods and kits, thus generally described, will be understood more readily by reference to the following examples, which are provided by way of illustration and are not intended to be limiting of the present methods and kits. The following is a description of the materials and experimental procedures used in the example.

Materials and Methods

[0093]Study Subjects. A total of 283 subjects were studied. The first group consisted of 105 patients with liver cirrhosis complicated by HCC. The diagnosis of HCC was confirmed by biopsy and histological evaluation or detection of new hepatic lesion with arterial phase enhancement on computed tomography or magnetic resonance imaging. The second group included 107 patients with chronic liver diseases (CLDs) and no HCC. All patients had biopsies reviewed by a pathologist, fibrosis staging between 0 and 4 (metavir scale), and variable degrees of inflammation. The clinical follow up in this group included ultrasound and AFP measur...

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Abstract

Provided herein are methods for the diagnosis, or management of liver diseases, e.g., hepatocellular carcinoma, using profiles of the miRNAs determined from cellular or acellular body fluids.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims benefit of U.S. Provisional Application 61 / 313,677, filed Mar. 12, 2010, which is herein incorporated by reference in its entirety.FIELD OF THE INVENTION[0002]The invention generally relates to the diagnosis, prognosis, and / or management of liver diseases including hepatocellular carcinoma.BACKGROUND OF THE INVENTION[0003]The following discussion of the background of the invention is merely provided to aid the reader in understanding the invention and is not admitted to describe or constitute prior art to the present invention.[0004]Hepatocellular carcinoma (HCC), the fifth most common solid tumor in the world, has shown a rising trend in terms of both incidence and mortality in the United States. These increases are largely associated with cirrhosis due to chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, alcohol abuse, and other causes. Current diagnosis of HCC in patients with clinical suspi...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C12Q1/68G01N33/48
CPCC12Q1/6886G01N2333/471G01N33/57438C12Q2600/178
Inventor QU, KEVINZHANG, KEALBITAR, MAHER
Owner QUEST DIAGNOSTICS INVESTMENTS INC
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