Use of deuterium depleted water for the treatment of insulin resistance

Inactive Publication Date: 2014-05-22
HYD RAKKUTATO & GYOGYSZERFEJLESZTO
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  • Application Information

AI Technical Summary

Benefits of technology

The invention provides a novel way to prepare and process a certain material. This method has several benefits, including improving the efficiency and accuracy of the process.

Problems solved by technology

Unfortunately, this can be hardly achieved and kept for longer periods, which leads to the complications described above.
These cases confirmed that the cancer cells are sensitive to D depletion and in the majority of cases (70-80%) cannot adapt to the altered environment, resulting in shrinkage or even total elimination of the tumor.
However, the description of that patent does not mention that DDW is suitable for treatment of insulin resistance, or that water with 105-125 ppm D-level is optimal for that effect (see below).

Method used

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  • Use of deuterium depleted water for the treatment of insulin resistance

Examples

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examples

[0051]The invention is exemplified with more details, without limiting the scope of protection, hereunder:

[0052]A) Pharmacological Example

[0053]In the rat model system, animals pretreated with streptozotocin (STZ) were treated with water having various deuterium concentrations for 4 weeks in several independent experiments. The rats had daily two insulin treatments with 1 IU, the control group consumed normal water (150 ppm) while the treated groups consumed DDW of 25, 70, 105, 125, 130, 135, 140 and 145 ppm D level. To find out what mechanism is responsible for the lower blood sugar levels found in the rats drinking DDW, the amount of GLUT4 protein in the rats' muscle cell membrane was determined The rightmost two empty bars in FIG. 1 show that in rats not pretreated with STZ the amount of GLUT4 was not influenced by the D concentration (25-150 ppm) of the water they consumed. The five dark bars on the left side of the figure show that, among the STZ-pretreated rats, the lowest GLU...

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Abstract

The invention relates deuterium depleted water containing 0.01 to 135 ppm deuterium, preferably 105 to 125 ppm deuterium, for use in the treatment of insulin resistance.Further object of the invention is deuterium depleted food product containing 0.01 to 135 ppm deuterium, preferably 105 to 125 ppm deuterium, for use in the treatment of insulin resistance.

Description

[0001]The invention relates to pharmaceutical and food products containing deuterium depleted water, suitable for the treatment of insulin resistance.TECHNICAL BACKGROUND[0002]Diabetes mellitus (DM) is a chronic disease of human metabolism. The cause of disease is lack of insulin, a hormone produced by the pancreas, or the insensitivity to insulin within the organism (insulin resistance, relative lack of insulin), or both. Due to the absolute or relative lack of insulin the cells are unable to take up glucose, that is why the blood glucose level increases (hyperglycemia) leading to the symptoms of the disease. The patients' blood glucose level is in such cases higher than the normal range of 3.5-6.5 mmol / L. It is common for persons in this disease group that, in spite of different pathogenesis, they cannot secrete the amount of insulin required by their metabolic processes, or insulin, although present, has no effect.[0003]From diagnostic aspect, diabetes mellitus (DM) has three sub...

Claims

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Application Information

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IPC IPC(8): A61K33/00A61K31/70A61K38/00
CPCA61K33/00A61K38/00A61K31/70A61P3/08A61P3/10
InventorSOMLYAI, GABOR
OwnerHYD RAKKUTATO & GYOGYSZERFEJLESZTO