Blood biomarkers for suicidality

a blood biomarker and suicidal risk technology, applied in the field of gene expression biomarkers, can solve the problems of no objective tools to assess and track changes in suicidal risk, suicide is a leading cause of death in psychiatric patients, etc., and achieve the effect of sufficient monitoring and treatmen

Inactive Publication Date: 2014-08-28
INDIANA UNIV RES & TECH CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0008]By monitoring and tracking changes in suicide state, the present disclosure allows for detection of an increased suicide risk prior to any suicide attempt by a subject, and further allows subjects at risk of suicide and other psychotic depressed mood states to be monitored

Problems solved by technology

Suicides are a leading cause of death in psychiatric patients, and in society at large.
There are current

Method used

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  • Blood biomarkers for suicidality
  • Blood biomarkers for suicidality
  • Blood biomarkers for suicidality

Examples

Experimental program
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example 1

Materials and Methods

[0050]In this Example, whole-genome gene expression profiling of blood samples was conducted to identify blood gene expression biomarkers for suicidality.

[0051]Human Subjects.

[0052]Male Caucasian subjects diagnosed with bipolar disorder (“Discovery Cohort”) were evaluated that had a diametrical change in suicidal ideation scores from no suicidal ideation to high suicidal ideation from visit to visit. The subjects were limited to minimize any potential gender-related and ethnicity-related state effects on gene expression. A demographic breakdown of the Discovery Cohort subjects is shown in Table 1A.

[0053]A “Validation Cohort”, in which the top biomarker findings from the Discovery Cohort testing were evaluated, consisted of an age-matched cohort of 9 male suicide completers obtained through the Marion County Coroner's Office (8 Caucasians, 1 African-American) (Table 1B). The subjects in the Validation Cohort were required to have a last observed alive post-mortem...

example 2

[0101]In this Example, SAT1 was validated by analyzing subsequent hospitalizations with and without suicidalilty and to previous hospitalizations with and without suicidality in two live follow-up cohorts, one bipolar (n=42) and one psychosis (schizophrenia / schizoaffective; n=46).

[0102]Particularly, the bipolar follow-up cohort (Table 9A) consisted of male Caucasian subjects in which whole-genome blood gene expression data, including levels of SAT 1, were obtained at the testing visits as described in Example 1. If the subjects had multiple testing visits, the visit with the highest SAT1 level was selected for this analysis. The subjects' subsequent number of hospitalizations with or without suicidality was tabulated from electronic medical records.

[0103]The psychosis (schizophrenia / schizoaffective) follow-up cohort (n=46) (Table 9B) similarly consisted of Caucasian subjects in which whole-genome blood gene expression data, including levels of SAT1, were obtained at testing visits a...

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Abstract

Biomarkers and methods for screening expression levels of the biomarkers for predicting and tracking suicidality, as well as for monitoring response to a treatment for suicidal risk and for determining suicidal risk as a side-effect of an antidepressant are disclosed.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to U.S. Provisional Patent Application No. 61 / 770,696 filed on Feb. 28, 2013, which is hereby incorporated by reference in its entirety.STATEMENT OF GOVERNMENT SUPPORT[0002]This invention was made with government support under D007363 awarded by the National Institutes of Health. The Government has certain rights in the invention.BACKGROUND OF THE DISCLOSURE[0003]The present disclosure relates generally to blood biomarkers and their use for predicting mental state, and in particular, for predicting a subjects' risk of suicide (also referred to herein as “suicidality”). More particularly, the present disclosure relates to gene expression biomarkers, and to methods of screening for biomarkers, for identifying subjects who are at risk of committing suicide and methods for monitoring response to potential treatments by analyzing biomarkers.[0004]Suicides are a leading cause of death in psychiatric patients, an...

Claims

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Application Information

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IPC IPC(8): C12Q1/68G01N33/68
CPCC12Q1/6883G01N33/6893C12Q2600/158G01N33/9466G01N2800/304G01N2800/52
Inventor NICULESCU, ALEXANDER B.
Owner INDIANA UNIV RES & TECH CORP
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