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Compositions and methods for treatment of kidney diseases

a technology for kidney diseases and compositions, applied in drug compositions, antibody medical ingredients, peptide/protein ingredients, etc., can solve the problems of increasing blood pressure, increasing the volume of fluid in the body, increasing blood pressure, etc., to enhance an immune response, and enhance an immune response

Active Publication Date: 2014-10-16
CARDIOVAX
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patent describes a composition that contains peptides from a protein called ApoB-100, as well as variants, mimics, and analogues thereof. These peptides can be used to enhance or induce an immune response, which can help treat, inhibit, prevent, or promote prophylaxis of kidney disease. The composition can be administered as a pharmaceutical or in a carrier that enhances the immune response.

Problems solved by technology

AngII is a potent vaso-active peptide which causes blood vessels to constrict, resulting in increased blood pressure.
This increases the volume of fluid in the body, which also increases blood pressure.

Method used

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Examples

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examples

[0117]The following example is provided to better illustrate the claimed invention and is not to be interpreted as limiting the scope of the invention. To the extent that specific materials are mentioned, it is merely for purposes of illustration and is not intended to limit the invention. One skilled in the art may develop equivalent means or reactants without the exercise of inventive capacity and without departing from the scope of the invention.

[0118]The inventors assessed the effect of p210 immunization on AngII-induced renal inflammatory responses in apoE (− / −) male mice. For the experiments described herein, native p210 peptide (KTTKQ SFDLS VKAQY KKNKH) was conjugated to cationic bovine serum albumin (cBSA) as carrier. Alum was used as an adjuvant. At 7, 10, and 12 weeks of age, male apoE (− / −) mice were subcutaneously injected with 100 μg of p210 / cBSA / Alum. As immunization controls, 100 μg of cBSA / Alum, or PBS were injected. At 10 weeks of age after first immunization booste...

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Abstract

The invention provides compositions comprising immunogenic fragments of ApoB-100 for eliciting an immune response in a subject or vaccinating a subject, so as to treat, prevent, 5 inhibit and / or reduce symptoms of kidney diseases in the subject. The compositions include immunogenic fragments of ApoB-100, CD8+ T cells activated with immunogenic fragments of ApoB-100 or a combination thereof.

Description

FIELD OF INVENTION[0001]The invention provides compositions and methods for treating kidney diseases in a subject in need thereof. The compositions include one or more peptides of ApoB-100 as set forth in Table 1 and / or derivatives, peptidomimetics, pharmaceutical equivalents and / or analogs thereofBACKGROUND OF THE INVENTION[0002]All publications cited herein are incorporated by reference in their entirety to the same extent as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference. The following description includes information that may be useful in understanding the present invention. It is not an admission that any of the information provided herein is prior art or relevant to the presently claimed invention, or that any publication specifically or implicitly referenced is prior art.[0003]The renin-angiotensin system (RAS) or the renin-angiotensin-aldosterone system (RAAS) is a hormone system that regulates...

Claims

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Application Information

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IPC IPC(8): C07K7/08A61K35/14
CPCA61K35/17C07K7/08A61K38/1709C07K14/775A61K39/0012A61K2039/55505A61K2039/6081A61P13/12A61K38/10
Inventor CHYU, KUANG-YUHSHAH, PREDIMAN K.DIMAYUGA, PAUL
Owner CARDIOVAX
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