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Ionization apparatus, mass spectrometer including ionization apparatus, and image forming system

a mass spectrometer and ionization technology, applied in the field of ionizing equipment, can solve the problems that the dissolved components at both measurement points cannot be analyzed correctly and separately

Inactive Publication Date: 2015-02-05
CANON KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides an ionization apparatus for extracting ions from a sample. The apparatus includes a holder for holding the sample, a probe for identifying the part of the sample to be ionized, an extract electrode for extracting the ionized ions, a liquid supply unit for providing liquid to the sample, and a unit for applying a first voltage between the probe and the extract electrode. The first voltage is pulse-modulated. The technical effect of this invention is to provide a more efficient and accurate method for ionizing samples.

Problems solved by technology

Therefore, depending on a condition such as the probe vibration or a solution flow rate, there is a problem in that when the components are consecutively measured by scanning the sample surface, sample components dissolved in the liquid bridge at a certain measurement point on the sample surface remain in another liquid bridge formed at a next measurement point, and hence the dissolved components at both measurement points cannot be analyzed correctly and separately.

Method used

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  • Ionization apparatus, mass spectrometer including ionization apparatus, and image forming system
  • Ionization apparatus, mass spectrometer including ionization apparatus, and image forming system
  • Ionization apparatus, mass spectrometer including ionization apparatus, and image forming system

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first embodiment

[0024]An ionization apparatus according to a first embodiment of the present invention includes a liquid supply unit for supplying solvent to a sample, a probe for forming a liquid bridge between the probe and the sample, an extract electrodeextract electrode for extracting ions, and a unit for applying a voltage between the probe and the extract electrodeextract electrode.

[0025]FIG. 1 is a schematic diagram illustrating an image forming system including the ionization apparatus according to the first embodiment of the present invention.

[0026]A sample 2 is placed on a holder 1 and is held by the holder 1. The sample 2 is a slice of a tissue (cells) of a living body or the like in this embodiment. The holder 1 is formed of a conductive material. The sample 2 may be placed on a flat substrate. In this case, a material of the substrate is appropriately selected from conductive or non-conductive materials in accordance with conductivity of the sample 2. If the sample 2 is conductive, it...

second embodiment

[0061]FIG. 3 is a schematic diagram illustrating an ionization apparatus according to a second embodiment of the present invention. In addition, FIGS. 4A and 4B show timings at which the voltage is applied.

[0062]In the second embodiment, in order to apply the voltage between the probe 3 or the solvent introduced to the probe 3 and the holder 1, a second voltage applying unit 102 is connected. Other structures are the same as those in the first embodiment.

[0063]The second voltage applying unit 102 is connected between the probe 3 or the solvent introduced to the probe 3 and the holder 1, and a pulse-modulated second voltage is intermittently applied. A pulse time of the second voltage is T3, and a time interval between pulses is T4. The second voltage is set to a few tens volts or lower. In addition, in parallel thereto, similarly to the first embodiment, the first voltage applying unit 101 applies the first voltage between the probe 3 and the extract electrode10. T4 is basically set...

third embodiment

[0071]FIG. 5 is a schematic diagram illustrating an ionization apparatus according to a third embodiment of the present invention. In this embodiment, compared with the second embodiment, the extract electrode 10 is separated from the introduction path 11 and is arranged at a position closer to the probe 3. Further, a intake electrode 13 is arranged close to the introduction path.

[0072]The first voltage applying unit 101 is connected between the extract electrode 10 and the conductive pipe 6 so that the first voltage is intermittently applied. A third voltage applying unit 103 is connected between the intake electrode 13 and the extract electrode 10 so that a third voltage is applied. The third voltage is a DC voltage. In addition, the second voltage applying unit 102 is connected between the conductive pipe 6 and the holder 1 so as to apply the second voltage. Other structures are the same as those in the first and second embodiments, and hence the detailed description thereof is o...

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Abstract

Provided is an ionization apparatus including: a holder configured to hold a sample; a probe configured to determine a part to be ionized of the sample held by the holder; an extract electrode configured to extract ionized ions of the sample; a liquid supply unit configured to supply liquid to a part of a region of the sample; and a unit configured to apply a first voltage between the probe and the extract electrode, in which the first voltage is pulse-modulated.

Description

BACKGROUND OF THE INVENTION[0001]1. Field of the Invention[0002]The present invention relates to an ionization apparatus for a solid sample, a mass spectrometer including the ionization apparatus, and an image forming system.[0003]2. Description of the Related Art[0004]There is a technology for ionizing a solid under the atmospheric pressure condition for component analysis of a surface of a solid sample.[0005]In the document Yoichi Otsuka et al., “Scanning probe electrospray ionization for ambient mass spectrometry”, Rapid Communications in mass spectrometry, 26, 2725 (2012), there is proposed an ionization method in which a very small volume of solvent is supplied to a very small region on a solid sample surface so that components of the sample are dissolved in the solvent, and then the components are ionized by an electrospray ionization method. The generated ions are introduced to a mass spectrometer so that a mass-to-charge ratio of the ion is measured, and hence the component ...

Claims

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Application Information

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IPC IPC(8): H01J49/04H01J49/10G01Q10/06H01J49/40H01J49/00
CPCH01J49/0413H01J49/40H01J49/0459H01J49/0004G01Q10/065H01J49/10
Inventor KYOGAKU, MASAFUMIOTSUKA, YOICHI
Owner CANON KK