Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Topical compositions and methods for skin lightening

a composition and skin technology, applied in the field of dermatological compositions and methods, can solve the problems that the use of histamine antagonists to reduce pigmentation has received little attention to date, and achieve the effects of reducing pigmentation in human skin, reducing histamine-induced pigmentation, and reducing the appearance of liver spots, freckles, and mottled and discrete pigmentation

Inactive Publication Date: 2016-09-15
AVON PROD INC
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention provides compounds that can reduce pigmentation in human skin by blocking the action of histamine, a substance that causes pigmentation. These compounds can be applied directly to the skin and are effective in treating various hyperpigmentation skin conditions, including age spots, freckles, and melasma. They can also be used to lighten the skin and improve signs of aging. The compounds work by blocking the histamine receptor in the skin, which reduces the production of melanin, a pigment that causes colored spots.

Problems solved by technology

However, the use of histamine antagonists to reduce pigmentation has received little attention to date.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Topical compositions and methods for skin lightening
  • Topical compositions and methods for skin lightening
  • Topical compositions and methods for skin lightening

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0100]The Compound of Formula (II) was examined for its ability to reduce pigmentation in vitro in human melanocytes. Human epidermal melanocytes from dark-pigmented skin were seeded in 6-well dishes and grown using commercially available Medium 254, a sterile, liquid medium prepared with 200 μM calcium chloride for the culture of human epidermal melanocytes, supplemented with 1% Penicillin / Streptomycin and 1% Human Melanocyte Growth Supplement. Histamine, Diphenhydramine HCl and Compound II were added to the growth medium at the concentrations listed in Table 1 below. Corresponding controls were maintained without histamine, Diphenylhydramine HCl and Compound II. Four replicates were tested for each combination. After 8 days of incubation, melanin was collected and processed by washing the wells with IX phosphate-buffered saline (PBS), followed by addition of 200 μL of 2M NaOH to three of the four replicates, which are then scraped, pooled and boiled at 80° C. for an hour. Melanin ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
structureaaaaaaaaaa
aliphaticaaaaaaaaaa
weightaaaaaaaaaa
Login to View More

Abstract

Embodiments of the invention are generally directed to compositions useful for reducing pigmentation in the skin. The composition may further include other depigmenting agents such as nicotinamide and its melanasome transfer-inhibiting derivatives, 3,3′-thiodipropanoic acid and its tyrosinase-inhibiting derivatives, or resorcinol and its tyrosinase-inhibiting derivatives, in a topically acceptable vehicle.

Description

FIELD OF INVENTION[0001]The invention relates generally to cosmetic and dermatological compositions and methods for reducing pigmentation in human integuments. More particularly, the invention provides topical compositions and associated methods for treatment of hyperpigmentation or reduction of unwanted pigmentation. The compositions may be applied topically to skin to reduce pigmentation in the area of application.BACKGROUND[0002]The color of human skin is due primarily to the production of melanin by specialized cells in the skin called melanocytes through a process known as melanogenesis. The synthesis of melanin is a complex process involving several biochemical pathways. It is generally recognized that pigmentation may accompany inflammatory processes. Histamine is an agent involved in the inflammatory response which is reported to increase tyrosinase activity in human melanocytes, with the effects being completely inhibited by histamine antagonists such as famotidine. Histami...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(United States)
IPC IPC(8): A61K8/49A61Q19/02A61K8/46A61K8/36A61K8/06A61K8/34
CPCA61K8/4926A61K8/06A61K8/064A61K8/062A61K8/342A61K8/46A61K2800/524A61K8/36A61Q19/02A61K2800/48A61K2800/54A61K2800/42A61K2800/522A61K8/347A61K8/675A61P17/00A61K8/49
Inventor HU, HONGYIM, SUNGHANSANTHANAM, UMALYGA, JOHN W.
Owner AVON PROD INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com