The invention discloses a nonapeptide-1 derivative and its synthesis method and application, belonging to the technical field of cosmetic peptides, using nonapeptide-1, asiatic acid or hydroxyasiatic acid as raw materials, nonapeptide-1 and asiatic acid The molar ratio of nonapeptide-1 and madecassic acid is 1: 2.0-4.0, or the molar ratio of nonapeptide-1 and madecassic acid is 1: 2.0-4.0, with HOBt / DCC or DMAP / DCC as condensing agent, carry out condensation reaction, obtain nine Peptide-1 derivatives. The nonapeptide-1 derivative of the present invention has inhibitory tyrosinase activity, antioxidant activity, anti-photoaging activity, anti-sensitivity activity, and good transdermal permeability, and can be used to prepare skin depigmentation agents, whitening agents, and light spots Agents, anti-aging agents, anti-sensitivity agents.