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Preparation of emulsifiable paste for containing decoloring agent, tretinoin and skinniness steroids

A technology of corticosteroids and decolorizing agents, which can be used in medical preparations containing active ingredients, medical preparations without active ingredients, and skin diseases, etc.

Inactive Publication Date: 2008-08-27
CHONGQING PHARMA RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The cream prepared according to the method and experimental conditions of this patent, although the content uniformity of retinoic acid is slightly better than that of US2003033876, is still not ideal, and a grinding process is added, which is time-consuming, laborious and energy-intensive

Method used

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  • Preparation of emulsifiable paste for containing decoloring agent, tretinoin and skinniness steroids
  • Preparation of emulsifiable paste for containing decoloring agent, tretinoin and skinniness steroids

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] First, mix 64.0 grams of cetearyl alcohol, 48.0 grams of octadecanoic acid, 40.0 grams of glycerin, and 0.16 grams of propylparaben (also known as propylparaben) and heat to 75 ° C to form a uniform oil phase ;

[0087] In the second step, mix and heat 24.0 grams of magnesium aluminum silicate, 484 grams of distilled water, and 1.44 grams of methylparaben (also known as nimethyl ester) to 75 ° C, and stir for about 2 hours to make the magnesium aluminum silicate fully water into a colloidal aqueous phase;

[0088] In the third step, add the oil phase to the water phase, add 3.6 grams of triethanolamine while stirring, then homogenize into a milky white emulsion with a Fluke high-speed homogenizer, continue to stir and cool to 60°C to form a cream base;

[0089] In the fourth step, under the dark operation, easily add 0.4 g of BHT, 0.4 g of citric acid, 0.4 g of retinoic acid, and 0.08 g of fluorine acetate into 100.0 g of polyethylene glycol 400, stir and dissolve into...

Embodiment 2

[0146] First, mix 64.0 grams of cetearyl alcohol, 48.0 grams of stearic acid, 40.0 grams of glycerin, and 0.16 grams of propylparaben and heat to 75° C. to form a uniform oil phase;

[0147] In the second step, 24.0 grams of magnesium aluminum silicate, 484 grams of distilled water, and 1.44 grams of methylparaben were mixed and heated to 75°C, and stirred for about 2 hours to fully hydrate the magnesium aluminum silicate into a colloidal water phase;

[0148] In the third step, add the oil phase to the water phase, add 3.6 grams of triethanolamine while stirring, and then homogenize into a milky white emulsion with Fluke at high speed, continue to stir and cool to 60°C to form a cream base;

[0149] In the fourth step, under the dark operation, easily add 0.4 g of BHT, 0.4 g of citric acid, 0.4 g of retinoic acid, and 0.08 g of fluorine acetate into 100.0 g of polyethylene glycol 400, stir and dissolve into a yellow Granular yellow suspension;

[0150] The fifth step is to a...

Embodiment 3

[0157] First, mix 64.0 grams of cetearyl alcohol, 48.0 grams of stearic acid, 40.0 grams of glycerin, and 0.16 grams of propylparaben and heat to 75° C. to form a uniform oil phase;

[0158] In the second step, 24.0 grams of magnesium aluminum silicate, 484 grams of distilled water, and 1.44 grams of methylparaben were mixed and heated to 75°C, and stirred for about 2 hours to fully hydrate the magnesium aluminum silicate into a colloidal water phase;

[0159] In the third step, add the oil phase to the water phase, add 3.6 grams of triethanolamine while stirring, and then homogenize into a milky white emulsion with Fluke at high speed, continue to stir and cool to 60°C to form a cream base;

[0160] In the fourth step, under the dark operation, easily add 0.4 g of BHT, 0.4 g of citric acid, 0.4 g of retinoic acid, and 0.08 g of fluorine acetate into 100.0 g of polyethylene glycol 400, stir and dissolve into a yellow Granular yellow suspension;

[0161] The fifth step is to ...

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Abstract

The invention discloses a preparation method of cream containing decolorant, tretinoin and corticosteroids. The cream prepared by the method has good uniformity and stability. The method facilitates the quality control of the cream during the production and ensures the validity and safety of the cream product.

Description

Technical field: [0001] The invention belongs to the field of preparation methods of pharmaceutical preparations, and in particular relates to the preparation of creams containing hydroquinone, tretinoin, corticosteroids and their derivatives. technical background: [0002] Melasma, also known as liver spots, is also known as "butterfly spots", which is a common hyperpigmentation skin disease, which occurs on the sun-exposed parts of the face, such as cheeks, forehead, upper lip, nose and chin. Melasma has a butterfly-shaped distribution and is characterized by symmetrical hyperpigmentation, irregular shape, and light to brown color. [0003] The pathogenesis of chloasma is complicated, and the real cause of the disease is still not very clear. It is generally believed that chloasma is a chronic functional disease manifested on the face due to the imbalance of microcirculation function and pigment metabolism disorder caused by various reasons in the body. The onset of the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7034A61K9/06A61K47/34A61K47/38A61K47/44A61P17/00A61K31/19A61K31/215A61K31/573A61K31/58A61K47/10
Inventor 林佳亮朱正勇刘泽荣张涛牟才华邓杰
Owner CHONGQING PHARMA RES INST
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