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Cosmetic and/or dermatological use of a composition containing at least one oxidation-sensitive hydrophilic active principle stabilized by at least one maleic anhydride copolymer

A technology of maleic anhydride, active ingredients, applied in drug combination, skin diseases, emulsion delivery, etc., can solve problems such as lack of freshness

Inactive Publication Date: 2004-06-02
LOREAL SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main disadvantage of this solution is the lack of freshness when applied

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] Example 1: Accelerated storage test

[0087] The purpose of this test is to investigate the decomposition of oxidation-sensitive hydrophilic active ingredients after storage at 45°C for 2 months. Various solutions were prepared and their compositions are shown in the table below:

[0088] combination

[0089] The whole solution was adjusted to pH 6 with 8.9 mol / l KOH.

[0090] The percentages of polymer are based on active matter.

[0091] Polymer 1 : Styrene / maleic anhydride (50 / 50) copolymer in the form of 30% ammonium salt in water, by Atofina under the reference name SMA1000H  for sale.

[0092] Polymer 2 : Styrene / maleic anhydride (50 / 50) copolymer, in the form of the sodium salt, manufactured by Atofina under the reference name SMA1000HNa  for sale.

[0093] The degree of decomposition determined is expressed in the following scale:

[0094] (C 0 -C 2个月 ) / C 0

[0095] and there is C of ascorbic acid at t=0 0 Concentrati...

Embodiment 2

[0105] Example 2: The addition of the combination form of the present invention has an effect on the synthesis of tenascin and collagen VII. Observations of the resulting effects

[0106] This example describes the immunohistochemical labeling of proteins with tenascin and collagen VII by microscopic observation of skin sections, the effect of the addition of a combination of the invention (comprising ascorbic acid and a copolymer of the invention) on reconstituted skin.

[0107] 1. Preparation of Reconstituted Skin

[0108] The reconstituted skin used was prepared according to the protocol described by Asselineau et al. (Models in Dermato. Published by Loire and Maibach, 1987, Vol III, 1-7). Improvements to this scheme are described below:

[0109] -Normal adult skin fibroblasts per equivalent dermis 10 6 The proportion of cells used;

[0110] - The inoculation of keratinocytes is carried out at a ratio of 50 000 cells per ring with a diameter of 1.5 cm. The keratin...

Embodiment 3

[0123] Example 3: O / W Anti-Aging Cream

[0124] The following compositions were prepared in a manner conventional to those skilled in the art.

[0125] Phase A

[0126] Water 18.33g

[0127] Glycerin 3g

[0128] Phase B

[0129] Sorbitan Tristearate 0.68g

[0130] PEG-40 Stearate 1.5g

[0131] Cetyl Alcohol 3g

[0132] Glyceryl Stearate 2.25g

[0133] Myristyl myristate 1.5g

[0134] Ethylhexyl Palmitate 1.5g

[0135] Hydrogenated polyisobutylene 2.5g

[0136] Shorea robusta seed butter 1.5g

[0137] Shea (butyrospermum parkii) (shea butter) fruit 0.5g

[0138] Cyclopentasiloxane 7.5g

[0139] Phenoxyethanol 1g

[0140] Phase C

[0141] Water 43.94g

[0142] Ascorbic acid 5g

[0143] Potassium hydroxide (50% solution) 3g

[0144] Styrene / maleic anhydride copolymer, 30% ammonium salt in water 3.3g

[0145] (SMA1000H  , Atofina)

[0146] A thick and soft cream is obtained that combats the signs of aging, in which ascorbic acid has good stability over time. ...

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PUM

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Abstract

In a cosmetic composition containing an aqueous phase, a combination of at least one oxidation sensitive hydrophilic active principle (a) and at least one maleic anhydride copolymer (b) are used as depigmenting agents. (a) Is ascorbic acid or its derivatives. (b) Comprises at least one maleic anhydride comonomers and at least one of e.g. vinyl acetate, vinyl alcohol or styrene. In a cosmetic composition containing an aqueous phase, a combination of at least one oxidation sensitive hydrophilic active principle (a) and at least one maleic anhydride copolymer (b) are used as depigmenting agents. (a) Is ascorbic acid or its derivatives. (b) Comprises at least one maleic anhydride comonomers and at least one of vinyl acetate, vinyl alcohol, vinyl alcohol, vinyl pyrrolidone, olefins containing 2-20C atoms or styrene.

Description

technical field [0001] The present invention relates to the cosmetic and / or dermatological application of a composition comprising at least one oxidation-sensitive hydrophilic active ingredient and at least one maleic anhydride copolymer in a physiologically acceptable medium comprising an aqueous phase. Background technique [0002] It is known that various active ingredients can be incorporated into cosmetic compositions for specific treatment of the skin and / or hair. However, some of these active ingredients have the disadvantage of being unstable in aqueous media and easily decomposing in contact with water, especially due to oxidation phenomena. They therefore lose their activity rapidly over time, and this instability conflicts with the expected effectiveness. [0003] Attempts have long been made to formulate ascorbic acid or vitamin C due to its many beneficial properties. In particular, ascorbic acid promotes the synthesis of connective tissue and especially colla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/113A61P17/16
Inventor B·比亚特里
Owner LOREAL SA
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