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Therapeutic SALL4 Peptide

a technology of sall4 and peptide, which is applied in the direction of peptides, peptide/protein ingredients, chemistry apparatus and processes, etc., to achieve the effect of fewer side effects

Active Publication Date: 2019-07-18
NAT UNIV OF SINGAPORE +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent describes a group of peptides that target a protein called SALL4, which is associated with disease. These peptides are selective, meaning they are specifically designed to target SALL4. This is important because selectivity helps reduce the risk of side effects when using peptides for therapeutic purposes. The described peptides have a variety of applications, including use in treating diseases and promoting tissue regeneration.

Problems solved by technology

However SALL4 falls into a class of so-called undruggable targets, as it lacks a typical, druggable pocket for inhibitor binding.

Method used

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  • Therapeutic SALL4 Peptide
  • Therapeutic SALL4 Peptide
  • Therapeutic SALL4 Peptide

Examples

Experimental program
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Embodiment Construction

Isolated Peptides and Compositions Comprising Isolated Peptides

[0028]The present invention relates to isolated peptides comprising amino acids that are selected based on structure-function studies by the inventors on the interaction of a fragment of the human Spalt-Like Transcription Factor 4 (SALL4) with retinoblastoma binding protein 4 (RBBp4). The term “peptide” as used herein, refers to a compound having two or more amino acids linked in a chain, the carboxyl group of each acid being joined to the amino group of the next by a bond of the type —OC—NH—. A “peptide” is commonly known to those of skill in the art.

[0029]The present invention, in certain embodiments, provides isolated peptides comprising an amino acid sequence set forth in formula (I):

RRKX1X2X3X4X5X6X7  (I)

The sequence of amino acids in formula (I) follows the standard convention for representing amino acid sequences of peptides. Amino acids in formula (I) are written from the N-terminus (on the left) to the C-terminu...

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Abstract

The present invention provides, in certain embodiments, isolated peptides and pharmaceutical compositions comprising isolated peptides that bind to retinoblastoma binding protein 4 RBBp4 such that, the binding blocks the SALL4-RBBp4 interaction. Methods of inhibiting binding of SALL4 with RBBp4 and methods for treating a subject having a disorder mediated by a dysregulation of SALL4 are also provided.

Description

RELATED APPLICATION[0001]This application is the U.S. National Stage of International Application No. PCT / US2017 / 030164, filed Apr. 28, 2017, which designates the U.S., published in English, and claims the benefit of U.S. Provisional Application No. 62 / 329,010, filed on Apr. 28, 2016. The entire teachings of the above applications are incorporated herein by reference.INCORPORATION BY REFERENCE OF MATERIAL IN ASCII TEXT FILE[0002]This application incorporates by reference the Sequence Listing contained in the following ASCII text file being submitted concurrently herewith:[0003]a) File name: 44591138002CORRECTEDSEQUENCELISTING.txt; created Feb. 6, 2019, 14 KB in size.BACKGROUND OF THE INVENTION[0004]Spalt-Like Transcription Factor 4 (SALL4) plays an essential role in developmental events and the maintenance of stem cell pluripotency. SALL4 is a zinc finger transcription factor, that forms a core transcriptional network with POU5FI (Oct4), Nanog and Sox2, which activates genes related...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C07K7/06C07K7/08
CPCC07K7/06C07K7/08A61K38/00C07K2319/033
Inventor LIU, BEE HUITENEN, DANIEL GEOFFREYCHAI, LICHIA, CHENG SAN BRIANPOULSEN, ANDERS
Owner NAT UNIV OF SINGAPORE
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