Prophylactic and therapeutic treatment of alzheimer's disease using phytic acid and phytate to reduce amyloid beta plaque and tau protein

a technology of amyloid beta plaque and tau protein, applied in the field of phytic acid and phytate for the treatment of alzheimer's disease, can solve problems such as burdensome doses, and achieve the effect of preventing the occurrence of potential side effects, treating and preventing the aggregation of beta amyloid proteins

Inactive Publication Date: 2020-03-12
SABIN ROBERT
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  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0016]Surprisingly, it has been discovered that very low doses of phytic acid, phytate salt, an isomer or hydrolysate of phytic acid or a phytate salt, or a mixture of any combination thereof are effective in the treatment and prevention of aggregation of beta amyloid proteins as are commonly seen in the brains of Alzheimer's patients. Treatment with such a low dose of phytic acid, phytate salt, an isomer or hydrolysate of phytic acid or a phytate salt, or a mixture of any combination thereof prevents the occurrence of potential side effects observed with high dose treatments and allows for ease of administration to Alzheimer's patients who may find it difficult to take high doses of the substance. Furthermore, it has been discovered that phytic acid, phytate salt, an isomer or hydrolysate of phytic acid or a phytate salt, or a mixture of any combination thereof is much more effective than scyllo inositol and myo inositol.

Problems solved by technology

This dose is burdensome.

Method used

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  • Prophylactic and therapeutic treatment of alzheimer's disease using phytic acid and phytate to reduce amyloid beta plaque and tau protein
  • Prophylactic and therapeutic treatment of alzheimer's disease using phytic acid and phytate to reduce amyloid beta plaque and tau protein
  • Prophylactic and therapeutic treatment of alzheimer's disease using phytic acid and phytate to reduce amyloid beta plaque and tau protein

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[0039]The Applicant tested compounds disclosed in the above referenced patents of Sabin using well established standard routine testing, as known in the art, at Oregon Science and Health University in an in-vitro challenge test.

[0040]The Applicant submits two pages of the data of these in vitro tests. In the first test, phytic acid attenuates APP CTF-induced neurotoxicity. APP is a precursor / source to beta amyloid plaque and is considered by many to be a “bad actor”, “cause”, of Alzheimer's Disease. See DDN BENCH PRESS. Neither scyllo inositol nor myo inositol previously used by Barak et al, “inositol treatment of Alzheimer's disease: a double blind, cross-over placebo controlled trial”, Prog. Neuro-Psychopharmacol. & Biol. Psychiatry., 20(4): 729-735, 1996 attenuated APP CTF-induced neurotoxicity. Phytic acid is shown to be active, while scyllo inositol and myo inositol are shown to be inactive. These surprising and unexpected results with phytic acid attenuating APP CTF-induced ne...

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Abstract

A composition and method for the treatment of Alzheimer's disease and related amyloid plaque development and reduction of amyloid plaque, amyloidosis and amyotrophic lateral sclerosis, includes an effective amount of a compound selected from the group consisting of phytic acid, a phytate salt, an isomer or hydrolysate of phytic acid or a phytate salt, or a mixture of any combination thereof, being administered to a person in an amount from about 0.5 grams to about 18.75 grams per day.

Description

RELATED APPLICATIONS[0001]This application is a continuation of application Ser. No. 12 / 661,964, filed Mar. 26, 2010, which '964 application is incorporated by reference herein and claims benefit therefrom under 35 USC section 120. This application and the aforementioned '964 application are based upon, and claim priority under 35 USC 119 (e), from provisional application No. 61 / 211,230 filed Mar. 27, 2009 and provisional application No. 61 / 273,126, filed Jul. 29, 2009. The '230 and the '126 provisional applications are incorporated by reference herein.[0002]All Patents, Scientific Articles, and other Documents mentioned herein are incorporated by reference as if reproduced in full below.FIELD OF THE INVENTION[0003]This invention relates to the prophylactic and therapeutic treatment of Alzheimer's Disease, herein-below identified as “AD”.BACKGROUND OF THE INVENTION[0004]Phytic acid, generally accepted as having the structure myo-inositol-hexakis (dihydrogen phosphate), is a major co...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/66A61K9/19A61K9/00A61K9/20
CPCA61K9/19A61K9/0014A61K9/0021A61K9/2004A61K9/0095A61K31/66A61P25/00A61P25/28A61K31/6615
Inventor SABIN, ROBERT
Owner SABIN ROBERT
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