Prophylactic and therapeutic treatment of Alzheimer's disease using phytic acid and phytate to reduce amyloid beta plaque and tau protein

Abstract

A composition and method for the treatment of Alzheimer's disease and related amyloid plaque development and reduction of amyloid plaque, amyloidosis and amyotrophic lateral sclerosis, includes an effective amount of a compound selected from the group consisting of phytic acid, a phytate salt, an isomer or hydrolysate of phytic acid or a phytate salt, or a mixture of any combination thereof, being administered to a person in an amount from about 0.5 grams to about 18.75 grams per day.

Description

RELATED APPLICATIONS[0001]This application claims priority from provisional application No. 61 / 211,230 filed Mar. 27, 2009 and provisional application No. 61 / 273,126, filed Jul. 29, 2009 and claims benefit and priority under 35 U.S.C. §119(e). These applications are incorporated by reference herein.[0002]All Patents, Scientific Articles, and other Documents mentioned herein are incorporated by reference as if reproduced in full below.FIELD OF THE INVENTION[0003]This invention relates to the prophylactic and therapeutic treatment of Alzheimer's Disease, herein-below identified as “AD”.BACKGROUND OF THE INVENTION[0004]Phytic acid, generally accepted as having the structure myo-inositol-hexakis (dihydrogen phosphate), is a major component of plant seeds, constituting 1-3% by weight of many cereals and oil seeds. Most wheat brans contain between 4 and 5% phytic acid. Phytic acid may be prepared in pure form from various plant sources, such as wheat, corn, soybeans, sesame seeds, peanuts...

AI Technical Summary

Benefits of technology

[0016]Surprisingly, it has been discovered that very low doses of phytic acid, phytate salt, an isomer or hydrolysate of phytic acid or a phytate salt, or a mixture of any combination thereof are effective in the treatment and prevention of aggregation of beta amyloid proteins as are commonly seen in the brains of Alzheimer's patients. Treatment with such a low dose of phytic acid, phytate salt, an isomer or hydrolysate of phytic acid or a phytate salt, or a mixture of any combination thereof prevents the occurrence of potential side effects observed with high dose treatments and allows for ease of administration to Alzheimer's patients who may find it difficult to take high doses of the substance. Furthermore, it has been discovered that phytic acid, phytate salt, an isomer or hydrolysate of phytic acid or a phytate salt, or a mixture of any combination thereof is much more effective than scyllo inositol and myo inositol.

Problems solved by technology

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