Devices and methods for precision dose delivery

Abstract

Disclosed herein are delivery devices for delivering a volume of a drug product, placebo product, or other product including a fluid. The devices may include a barrel having a longitudinal axis, a proximal end region, and a distal end region. The proximal end region may include an opening, and the barrel may be configured to receive a drug therein. A plunger rod may be disposed at least partially inside the barrel and protruding from the opening. The plunger rod may include a rack having a plurality of teeth. The device may further include a pinion having a plurality of teeth configured to engage with the plurality of teeth of the rack, and rotation of the pinion against the rack may move at least a part of the plunger rod along the longitudinal axis of the barrel.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to U.S. Application No. 62 / 598,212, filed Dec. 13, 2017; U.S. Application No. 62 / 676,047, filed May 24, 2018; and U.S. Application No. 62 / 722,252, filed Aug. 24, 2018, all of which are incorporated by reference herein in their entireties.FIELD OF DISCLOSURE[0002]Aspects of the present disclosure relate to devices and methods for priming or otherwise configuring a dose delivery device, e.g., a syringe, to promote precision dose delivery. More specifically, embodiments of the present disclosure relate to devices and methods for loading, storing, transporting, and / or delivering precise doses of a drug product, placebo product, or other product including a fluid.INTRODUCTION[0003]Liquid drug products may be deliverable to patients in a variety of ways, including via injection. In many cases, the precision and accuracy of a liquid drug product's volume is crucial. For example, medical professionals may have an ...

AI Technical Summary

Benefits of technology

These devices enhance precision and accuracy in delivering small drug volumes by allowing users to set and confirm doses with reduced human error, ensuring the correct dose is administered while preventing air bubble injection and over / under-dosing, thus improving clinical outcomes.

Problems solved by technology

Additionally, over- or under-dosing a patient with a drug product, even slightly, may have an undesired (or even negative) clinical impact on the patient.

At low volumes, human error in preparing and delivering an accurate dose of a drug product for injection may impact the drug's efficacy in a patient and the subsequent clinical effect on the patient.

Additional aspects of liquid drug product delivery can complicate the goal of accurate dose delivery via injection.

Additionally, prior to administration of a drug product from a device, the device may need to be primed to remove air bubbles from within the device's needle and barrel.

Incorrectly priming a device may result in expulsion of too much or too little drug product from the device, which likewise may result in a decreased dose being delivered to a patient, or air bubbles being injected from the device into the patient.

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