Polyinosinic acid-polycytidylic acid-based adjuvant

a polycytidylic acid and polyinosinic acid technology, applied in the field of adjuvant compositions, can solve the problems of eliciting unacceptable adverse side effects, and achieve the effect of enhancing the antigenicity of an antigenic compound
US7838017B2Active Publication Date: 2010-11-23YISHENG BIOPHARMA SINGAPORE
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Patents(United States)
Current Assignee / Owner
YISHENG BIOPHARMA SINGAPORE
Publication Date
2010-11-23

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Abstract

The present invention provides a polynucleotide adjuvant composition and methods of use in eliciting an immune response. The present invention also provides an immunogenic composition comprising the polynucleotide adjuvant composition together with an antigen (e.g., as in a vaccine). The adjuvant compositions of the invention have particular physical properties (e.g., molecular weight, concentration, and pH) which address the need for a safe adjuvant for eliciting an enhanced immune response. The present invention further contemplates methods of use of such adjuvant compositions, particularly in eliciting an immune response to an antigenic compound.
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Description

FIELD OF INVENTION

[0001] The invention generally relates to adjuvant compositions and methods of their use in enhancing an immune response, more particularly to compounds, vaccines and methods for enhancing the immunogenicity of an antigen, and more particularly to polynucleotide adjuvant compositions, vaccines comprising the polynucleotide adjuvant compositions, and methods of using said polynucleotide adjuvant compositions and vaccines to enhance immune responses in a host.BACKGROUND OF INVENTIONDescription of Related Art

[0002] The immune system may exhibit both specific and nonspecific immunity. Generally, B and T lymphocytes, which display specific receptors on their cell surface for a given antigen, produce specific immunity. The immune system may respond to different antigens in two ways: 1) humoral-mediated immunity, which includes B cell stimulation and production of antibodies or immunoglobulins, antigen-presenting cells (APCs), and helper T cells (Th1 and Th2), and 2) cell-m...

Claims

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