Method and apparatus for mass spectrometry

Abstract

For the achievement of data transfer time reduction, removal of noise data, and analytical efficiency improvement in an ADC data processing function of a time-of-flight mass spectrometer, the mass spectrometer comprises a data acquisition circuit including: an A / D converter; a signal intensity addition memory that stores data of ion signals such as a time range and the number of measurements and performs an addition process; a voltage value frequency addition memory that performs an addition process of frequencies of voltage values of the predetermined time range and the number of measurements and stores addition results; a threshold level computation circuit that computes a predetermined threshold level from the results in the memory; a compression memory that extracts only data exceeding the threshold level from the data in the signal intensity addition memory; and a counter that controls a measurement time for data acquisition and the operation of each circuit.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]The present application claims priority from Japanese Patent Application No. JP 2005-50102 filed on Feb. 25, 2005, the content of which is hereby incorporated by reference into this application.TECHNICAL FIELD OF THE INVENTION[0002]The present invention relates to a mass spectrometry technology. More particularly, it relates to a technology effectively applied to data processing technologies for mass spectrometry using an A / D converter in a Time-of-Flight Mass Spectrometer (TOF-MS).BACKGROUND OF THE INVENTION[0003]FIG. 8 illustrates outlines of a TOF-MS using a data acquisition circuit studied by the inventors as a premise of the present invention.[0004]The TOF-MS is an apparatus in which a sample is ionized and accelerated in a space and a time of flight in the space, which depends on its mass, is measured, thereby analyzing components contained in the sample. The sample is ionized in an interface 1, and is then reached to a Time-of-Fligh...

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Benefits of technology

[0018]Accordingly, the present invention is to solve the above-described problems, and an object thereof is to provide a mass spectrometry technology capable of achieving a reduction in data transfer time by extracting and transferring only the data exceeding a threshold level, in an ADC data processing function of a time-of-flight mass spectrometer. Note that, in the present invention, simultaneously with a reduction in data transfer time, removal of noise data can be achieved.

[0019]Furthermore, another object of the present invention is to provide a mass spectrometry technology capable of achieving an improvement in analytical efficiency by extracting only the stored data required for the analysis.

[0022]In the present invention, in an ADC data processing function of a time-of-flight mass spectrometer, as means for extracting only a signal required for the analysis in a short time, a voltage value frequency addition memory circuit for adding frequencies of voltage values is provided, and a predetermined process is performed to determine a threshold level based on the noise distribution represented by the stored contents of the memory circuit. Then, only the data exceeding this threshold level is extracted and transferred. By doing so, a reduction in data transfer time can be achieved.

[0023]Also, in the present invention, the user of the apparatus refers to the contents of the above-described voltage value frequency addition memory circuit and a signal intensity addition memory circuit, and based on the reference result, a threshold level for discriminating between a noise value and a signal value is set, and then, only the stored data required for analysis is extracted. By doing so, an analytical efficiency can be improved.

[0030]According to the present invention, in an ADC data processing function, a voltage value frequency addition memory circuit for determining a threshold level and a data compression memory circuit for extracting only a signal exceeding the threshold level are provided. Therefore, data required for analysis can be easily compressed and a data transfer time can be reduced. As a result, a measurement suspension time of the apparatus can be reduced.

[0031]Also, according to the present invention, the determination and the setting of a threshold level at the time of data compression can be made by the apparatus user performing an arbitrary computation based on the time-based voltage value addition results and the voltage value frequency addition results. Therefore, the user can set an arbitrary discrimination value of a noise value and a signal value, and the efficiency of the analytical operation can be improved.

Problems solved by technology

However, since the next measurement cannot start during data transfer, all of the data transfer time corresponds to a measurement suspension time.

In this example, approximately 40% of the measurement time is a measurement suspension time, which leads to a degradation in measurement efficiency.

Sampling data from an A / D converter includes not only a peak spectrum but also a lot of unnecessary data such as a noise level, for example.

In these data compression processes, when data compression is performed to the addition data, since it is required that all pieces of measurement data are transferred to the CPU and then a compression process is performed by the CPU, a problem of increasing a measurement suspension time (data transfer time) occurs.

Therefore, a problem that the process becomes complicated and the cost is increased occurs.

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