Antiseptic solution of di(4-chloro-phenyldiguanido) compound and process therefor

a technology of di(4-chloro-phenyldiguanido) and antiseptic solution, which is applied in the direction of biocide, plant growth regulator, animal husbandry, etc., can solve the problem of reducing the absorption of isopropyl alcohol or chlorhexidine through skin, and achieves rapid onset of action, good pharmacokinetic properties, and long-lasting activity
US9149042B2Inactive Publication Date: 2015-10-06MEDICHEM
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Patents(United States)
Current Assignee / Owner
MEDICHEM
Publication Date
2015-10-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to a stable antiseptic solution comprising: a di(4-chlorophenyldiguanido) compound or a pharmaceutically acceptable salt thereof, wherein said di(4-chlorophenyldiguanido) compound or a pharmaceutically acceptable salt thereof is a compound of formula (I) or a pharmaceutically acceptable salt thereof. The invention further relates to a process for preparing said antiseptic solution.
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Description

CROSS-REFERENCE TO RELATED APPLICATION

[0001] This patent application claims the benefit of European Patent Application No. EP 11382069.0 filed on Mar. 14, 2011, Spanish Patent Application No. ES 201131038 filed on Jun. 20, 2011, European Patent Application No. EP 12158959.2 filed on Mar. 10, 2012, and U.S. Provisional Patent Application No. 61 / 500,969, filed Jun. 24, 2011, each of which is incorporated by reference. This patent application is a continuation-in-part of U.S. patent application Ser. No. 13 / 211,846 filed on Aug. 17, 2011, which is incorporated by reference.BACKGROUND OF THE INVENTION

[0002] Chlorhexidine is the international common accepted name for N,N-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (also known as 1,6-di(4″-chlorophenyldiguanido)hexane), and has an empirical formula of C22H30Cl2N10, a molecular weight of 505.45 g / mol, and a chemical structure of formula (I):

[0003]

[0004] Chlorhexidine is a well-known topical antiseptic and disinfec...

Claims

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