5 results about "Abrus precatorius" patented technology

This invention belongs to the field of traditional Chinese medicine and discloses the application of total saponins extract of *Abrus precatorius* in the preparation of drugs for treating metabolic-associated fatty liver disease (MAFLD). Through experiments in high-fat diet-induced MAFLD mice, this invention demonstrates that total saponins of *Abrus precatorius* can protect the liver from a series of damages caused by excessive lipid accumulation. The potential mechanisms include regulating lipid metabolism through the PPAR and AMPK signaling pathways, and modulating the balance of gut microbiota. These findings provide a solid research foundation and empirical evidence for the potential application of total saponins of *Abrus precatorius* in the treatment of MAFLD.

This invention discloses a water-oil dual-phase synergistic anti-fibrotic comprehensive formulation framework and its application based on Camellia chrysantha and Aristolochia debilis, belonging to the field of ethnic Zhuang medicine biomedicine and herbal chronic disease management technology. This invention is the first to fix Camellia chrysantha and Aristolochia debilis as the unique dual-core framework, creating a novel dual-phase synergistic underlying pharmacology of water-phase flavonoids against organ fibrosis and oil-phase α-linolenic acid for anti-inflammatory and plaque-stabilizing effects. It constructs a three-tiered comprehensive application system covering daily health maintenance, organ damage repair, early-stage fibrosis, and blocking of high-risk vascular lesions. This system can be extended to adapt to various chronic disease herbal compositions and industrial applications in multiple dosage forms such as tea, granules, and capsules. This invention is highly original, has a closed-loop pharmacological logic, and is highly applicable, filling the gap in existing technologies for fixed dual-core formulations and water-oil dual-phase comprehensive conditioning frameworks. It possesses extremely high scientific research value, intellectual property barriers, and industrial application value.

The invention provides a traditional Chinese medicine enteric-coated preparation for treating pet diarrhea, and relates to the technical field of traditional Chinese veterinary medicine pharmacy. The traditional Chinese medicine composition is prepared by subtle compatibility of monarch, minister, assistant and guide according to the traditional Chinese veterinary dialectical treatment principle aiming at spleen-deficiency damp-heat type diarrhea of pet cats and dogs. The traditional Chinese medicine enteric-coated preparation is mainly prepared from radix fici simplicissimae, abrus cantoniensis hance, semen sterculiae nobilis, verbena, polyporus umbellatus, pterocephalus hookeri, coptis chinensis, rehmannia, emblic leafflower fruit, travertine, lotus seeds and liquorice as traditional Chinese medicine raw materials, the whole formula uses cold and heat simultaneously, combines astringency removal and purgation and tonification simultaneously, not only removes the symptom of damp-heat stagnation in the intestinal tract, but also tonifies the root cause of weakness of the spleen and the stomach, and treats both symptoms and root causes. The traditional Chinese medicine enteric-coated preparation has an excellent treatment effect on cat and dog diarrhea caused by various reasons, clinical symptoms such as diarrhea, vomiting and watery stool of sick cats and dogs can be remarkably improved, and a new treatment scheme is provided for pet diarrhea.

The application relates to the technical field of traditional Chinese medicine compositions, and particularly discloses a homologous composition of medicine and food containing giant salamander peptide for dispelling alcohol and protecting liver and a preparation method thereof. The homologous composition of medicine and food containing giant salamander peptide for dispelling alcohol and protecting liver contains giant salamander peptide and a traditional Chinese medicine composite extract, and the traditional Chinese medicine composite extract is prepared by extracting raw materials including green tea, turmeric, mulberry leaves, hawthorn, radix puerariae, hovenia dulcis thunb, poria cocos, semen cassiae, lotus leaf powder, amomum kravanh, chrysanthemum, kudzuvine flower and abrus precatorius by a double solvent system of alcohol extraction and water extraction. The application can effectively avoid the negative interaction between some traditional Chinese medicine components and the giant salamander peptide, guarantee the activity and absorption utilization rate, significantly enhance the efficacy, realize the dispelling alcohol and protecting liver functions close to the expected effect, and finally obtain the homologous composition of medicine and food containing giant salamander peptide for dispelling alcohol and protecting liver with better application quality.

This invention belongs to the field of traditional Chinese medicine and discloses the application of total saponin extracts from *Abrus precatorius* in the preparation of drugs for treating and preventing liver injury caused by immune checkpoint inhibitors. This invention is the first to use total saponins from *Abrus precatorius* for preventative treatment of liver injury caused by immunosuppressants and has demonstrated significant efficacy. After preventative treatment with total saponins from *Abrus precatorius*, liver injury caused by immunosuppressants was significantly alleviated in Pdcd1 knockout C57BL / 6 mice, with a significant decrease in ALT and AST levels and a significant reduction in hepatic immune infiltration. Furthermore, transcriptome sequencing analysis showed that total saponins from *Abrus precatorius* mainly exert their pharmacological effects by inhibiting the activation of the cGAS-STING pathway, indicating that preventative administration of total saponins from *Abrus precatorius* can alleviate the pathological state and inflammatory level of ICI liver injury, thus showing promise for practical application.